CRCGN016_MCF10A.TP53.M_24H:C01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pcb126 10.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 4.50266
LYRM1 LYR motif containing 1 3.36648
TBPL1 TBP-like 1 3.35333
SSBP2 single-stranded DNA binding protein 2 3.11264
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.98036
ACAA1 acetyl-CoA acyltransferase 1 2.91718
MMP2 matrix metallopeptidase 2 2.81395
COMP cartilage oligomeric matrix protein 2.74616
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.64155
CCDC85B coiled-coil domain containing 85B 2.44166
CADM1 cell adhesion molecule 1 2.42878
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.34296
CERK ceramide kinase 2.3097
H2BC21 H2B clustered histone 21 2.15597
TMSB15C thymosin beta 15C 2.15152
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.12797
MOK MOK protein kinase 2.11132
CEP57 centrosomal protein 57kDa 2.08379
TPD52L2 tumor protein D52-like 2 2.05273
WDR11 WD repeat domain 11 2.03933
DENND2D DENN/MADD domain containing 2D 2.00815

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -4.85918
FPGS folylpolyglutamate synthase -4.17248
TRAPPC3 trafficking protein particle complex 3 -3.69448
CCNB1 cyclin B1 -3.67406
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.28072
ANKRD10 ankyrin repeat domain 10 -2.97952
BASP1 brain abundant, membrane attached signal protein 1 -2.78633
CBR3 carbonyl reductase 3 -2.77902
SLC35B1 solute carrier family 35, member B1 -2.76506
KIF14 kinesin family member 14 -2.59541
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.51547
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.3791
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.35217
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -2.35211
S100PBP S100P binding protein -2.30195
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.26569
TIMP1 TIMP metallopeptidase inhibitor 1 -2.23103
DCP1A decapping mRNA 1A -2.20147
DYNLT3 dynein, light chain, Tctex-type 3 -2.17656
R3HDM2 R3H domain containing 2 -2.13467
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.10819
LONP2 lon peptidase 2, peroxisomal -2.07775
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -2.05976
KPNA6 karyopherin alpha 6 (importin alpha 7) -2.01642
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.01566