CRCGN016_MCF10A.TP53.M_24H:C04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indirubin 100.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

19 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 3.75792
PPARG peroxisome proliferator-activated receptor gamma 3.58692
PDLIM1 PDZ and LIM domain 1 3.49786
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.45323
AMDHD2 amidohydrolase domain containing 2 3.26802
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.1844
CHEK1 checkpoint kinase 1 2.97839
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.96977
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.54366
CNRIP1 cannabinoid receptor interacting protein 1 2.28403
ALAS1 5'-aminolevulinate synthase 1 2.1554
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.114
BLTP2 bridge-like lipid transfer protein family member 2 2.02377

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.92702
DIPK1A divergent protein kinase domain 1A -3.53124
COG2 component of oligomeric golgi complex 2 -3.36225
HSPA1A heat shock 70kDa protein 1A -3.17496
LDHD lactate dehydrogenase D -2.89857
KDM3A lysine (K)-specific demethylase 3A -2.45882