CRCGN016_MCF10A.TP53.M_24H:C05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indirubin 33.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 5.86583
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.48746
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.8097
SNAP25 synaptosomal-associated protein, 25kDa 3.62143
ACAA1 acetyl-CoA acyltransferase 1 3.3101
KLHL9 kelch-like family member 9 2.94045
CADM1 cell adhesion molecule 1 2.804
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.76519
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.68641
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.66919
CYREN cell cycle regulator of NHEJ 2.65117
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.59433
RBBP5 retinoblastoma binding protein 5 2.48241
TPRA1 transmembrane protein, adipocyte asscociated 1 2.46053
HMOX1 heme oxygenase 1 2.30583
ADRM1 adhesion regulating molecule 1 2.29805
CGRRF1 cell growth regulator with ring finger domain 1 2.29257
POT1 protection of telomeres 1 2.27319
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.26534
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.25031
MDM4 MDM4, p53 regulator 2.20219
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 2.17478
HILPDA hypoxia inducible lipid droplet-associated 2.15448
AIRIM AFG2 interacting ribosome maturation factor 2.1462
FASTKD3 FAST kinase domains 3 2.14039
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.11155
WIF1 WNT inhibitory factor 1 2.10335
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.10331
PARP12 poly (ADP-ribose) polymerase family, member 12 2.08971
UNC50 unc-50 homolog (C. elegans) 2.07412
WDR91 WD repeat domain 91 2.07076
HOMER3 homer scaffolding protein 3 2.06217
SYT1 synaptotagmin I 2.04556
XPA xeroderma pigmentosum, complementation group A 2.02421
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.01823
MKRN1 makorin ring finger protein 1 2.01614
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.00403
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 2.00249

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.40707
BASP1 brain abundant, membrane attached signal protein 1 -3.78686
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.18917
MSN moesin -3.06757
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.9449
SGK1 serum/glucocorticoid regulated kinase 1 -2.64029
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.45551
CER1 cerberus 1, DAN family BMP antagonist -2.44764
OXA1L oxidase (cytochrome c) assembly 1-like -2.40122
WDR6 WD repeat domain 6 -2.39175
IQGAP1 IQ motif containing GTPase activating protein 1 -2.37738
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.31031
CDK6 cyclin-dependent kinase 6 -2.22879
REPS1 RALBP1 associated Eps domain containing 1 -2.22359
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.19564
CD207 CD207 molecule, langerin -2.15721
LMNB1 lamin B1 -2.13243
RHOT2 ras homolog family member T2 -2.10923
ANXA2 annexin A2 -2.09878
CCNG1 cyclin G1 -2.02337
XPO7 exportin 7 -2.02337
KDM1A lysine (K)-specific demethylase 1A -2.01485
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.00875
TNS2 tensin 2 -2.00815