CRCGN016_MCF10A.TP53.M_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cw-051 perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

296 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.84638
TXNRD1 thioredoxin reductase 1 9.14037
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 7.67742
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 7.6472
CTSL cathepsin L 5.81654
ASNS asparagine synthetase (glutamine-hydrolyzing) 5.26419
PHGDH phosphoglycerate dehydrogenase 5.24223
PSAT1 phosphoserine aminotransferase 1 5.15809
GARS1 glycyl-tRNA synthetase 1 4.93901
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 4.83272
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 4.8238
TOMM34 translocase of outer mitochondrial membrane 34 4.67896
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 4.66902
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.48893
PYCR1 pyrroline-5-carboxylate reductase 1 4.38671
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.38494
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 4.38458
RPL39L ribosomal protein L39-like 4.36551
CDCA4 cell division cycle associated 4 4.09259
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 4.00469
TRIB3 tribbles pseudokinase 3 3.99569
AARS1 alanyl-tRNA synthetase 1 3.93721
STK10 serine/threonine kinase 10 3.79323
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.77951
GCLM glutamate-cysteine ligase, modifier subunit 3.7517
XPOT exportin, tRNA 3.74379
SQSTM1 sequestosome 1 3.72081
KLHL21 kelch-like family member 21 3.69815
UGDH UDP-glucose 6-dehydrogenase 3.69366
C2CD2 C2 calcium-dependent domain containing 2 3.68259
GLRX glutaredoxin (thioltransferase) 3.65118
STX1A syntaxin 1A (brain) 3.63083
IL1B interleukin 1, beta 3.45643
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.43368
SH2D2A SH2 domain containing 2A 3.4101
SNAP25 synaptosomal-associated protein, 25kDa 3.35973
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.29738
UBQLN2 ubiquilin 2 3.28956
VSIG2 V-set and immunoglobulin domain containing 2 3.21669
YARS1 tyrosyl-tRNA synthetase 1 3.12454
CARS1 cysteinyl-tRNA synthetase 1 3.11825
FKBP14 FK506 binding protein 14, 22 kDa 3.0913
TBPL1 TBP-like 1 3.06814
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 3.05071
PPOX protoporphyrinogen oxidase 3.02792
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.01225
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 3.00064
TBXT T-box transcription factor T 2.99181
KLF10 Kruppel-like factor 10 2.98622
MRPL30 mitochondrial ribosomal protein L30 2.96025
CXCL2 chemokine (C-X-C motif) ligand 2 2.94471
FHL2 four and a half LIM domains 2 2.9419
TWF2 twinfilin actin binding protein 2 2.88658
EGR1 early growth response 1 2.81805
STAT4 signal transducer and activator of transcription 4 2.81229
RHOF ras homolog family member F (in filopodia) 2.80733
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.80716
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.78566
GRB10 growth factor receptor-bound protein 10 2.76105
MAMLD1 mastermind-like domain containing 1 2.75741
SARS1 seryl-tRNA synthetase 1 2.7231
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.70925
ABI2 abl-interactor 2 2.68709
ZMIZ1 zinc finger, MIZ-type containing 1 2.64925
ANO1 anoctamin 1, calcium activated chloride channel 2.63807
FOS FBJ murine osteosarcoma viral oncogene homolog 2.63022
ADGRE5 adhesion G protein-coupled receptor E5 2.62319
PRSS58 protease, serine, 58 2.60896
WIF1 WNT inhibitory factor 1 2.56827
E2F2 E2F transcription factor 2 2.56536
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.56021
INHBE inhibin, beta E 2.54136
ACAN aggrecan 2.53311
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.52017
MARS1 methionyl-tRNA synthetase 1 2.51049
ANKRD11 ankyrin repeat domain 11 2.46783
IER3 immediate early response 3 2.46536
CCR7 chemokine (C-C motif) receptor 7 2.45085
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.43984
PRB3 proline-rich protein BstNI subfamily 3 2.42892
FIP1L1 factor interacting with PAPOLA and CPSF1 2.42795
GPER1 G protein-coupled estrogen receptor 1 2.42583
NQO1 NAD(P)H dehydrogenase, quinone 1 2.40726
AGA aspartylglucosaminidase 2.40375
THAP3 THAP domain containing, apoptosis associated protein 3 2.39866
EGR3 early growth response 3 2.39379
P3H1 prolyl 3-hydroxylase 1 2.39376
SGSH N-sulfoglucosamine sulfohydrolase 2.39266
TRIB1 tribbles pseudokinase 1 2.3867
SH2B3 SH2B adaptor protein 3 2.38455
ECI1 enoyl-CoA delta isomerase 1 2.37764
GTPBP2 GTP binding protein 2 2.36875
GALE UDP-galactose-4-epimerase 2.36276
SCRG1 stimulator of chondrogenesis 1 2.35485
YIPF3 Yip1 domain family, member 3 2.34897
SIL1 SIL1 nucleotide exchange factor 2.33855
G0S2 G0/G1 switch 2 2.32706
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.32187
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.31908
TMEM165 transmembrane protein 165 2.31825
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.31574
ETFB electron-transfer-flavoprotein, beta polypeptide 2.28793
CEP85 centrosomal protein 85kDa 2.28022
KIF21B kinesin family member 21B 2.27913
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.27855
SBDS Shwachman-Bodian-Diamond syndrome 2.26501
ETV5 ets variant 5 2.26392
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.26055
LOC124907782 dual specificity protein phosphatase 22 2.26032
GPR171 G protein-coupled receptor 171 2.25495
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.24961
CHIC2 cysteine-rich hydrophobic domain 2 2.24921
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.24795
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.20835
SCG5 secretogranin V 2.20715
DUSP4 dual specificity phosphatase 4 2.205
NUCB2 nucleobindin 2 2.20351
EHBP1L1 EH domain binding protein 1-like 1 2.1998
PNKP polynucleotide kinase 3'-phosphatase 2.17909
PRB4 proline-rich protein BstNI subfamily 4 2.17336
SIRPG signal-regulatory protein gamma 2.16087
PCSK1 proprotein convertase subtilisin/kexin type 1 2.15818
GMIP GEM interacting protein 2.15675
DRD5 dopamine receptor D5 2.15257
ATF4 activating transcription factor 4 2.14513
LCN1 lipocalin 1 2.14288
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.13937
WDR91 WD repeat domain 91 2.13748
NECAB2 N-terminal EF-hand calcium binding protein 2 2.13289
GPC1 glypican 1 2.13255
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.12418
NDE1 nudE neurodevelopment protein 1 2.12051
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.11677
MZT2B mitotic spindle organizing protein 2B 2.10475
GOLT1A golgi transport 1A 2.10306
LPAR2 lysophosphatidic acid receptor 2 2.08719
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.08636
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.08164
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.07288
PPIF peptidylprolyl isomerase F 2.06842
CADM1 cell adhesion molecule 1 2.06522
LOC128125814 uncharacterized LOC128125814 2.06062
DUSP2 dual specificity phosphatase 2 2.0592
PID1 phosphotyrosine interaction domain containing 1 2.04909
GRK6 G protein-coupled receptor kinase 6 2.04366
FCMR Fc fragment of IgM receptor 2.03808
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.02891
STAMBP STAM binding protein 2.02313
ECH1 enoyl CoA hydratase 1, peroxisomal 2.02237
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.01202
MXD3 MAX dimerization protein 3 2.0102
NFE2 nuclear factor, erythroid 2 2.00674
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.00552

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -7.96434
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.62379
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -5.2266
PCNA proliferating cell nuclear antigen -4.82346
ADRB2 adrenoceptor beta 2, surface -4.77516
ZDHHC6 zinc finger, DHHC-type containing 6 -4.75463
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.63989
FASTKD5 FAST kinase domains 5 -4.21666
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.03782
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.99711
PRR15L proline rich 15-like -3.82104
S100A4 S100 calcium binding protein A4 -3.53209
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.52078
EIF5 eukaryotic translation initiation factor 5 -3.50041
NLRP4 NLR family, pyrin domain containing 4 -3.45926
DCK deoxycytidine kinase -3.43666
ANKRD10 ankyrin repeat domain 10 -3.43127
SMNDC1 survival motor neuron domain containing 1 -3.3739
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -3.34413
IDI1 isopentenyl-diphosphate delta isomerase 1 -3.28878
C2CD5 C2 calcium-dependent domain containing 5 -3.27594
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -3.2479
TRAPPC3 trafficking protein particle complex 3 -3.18408
YME1L1 YME1-like 1 ATPase -3.11431
HEXIM1 hexamethylene bis-acetamide inducible 1 -3.08846
TNIP1 TNFAIP3 interacting protein 1 -3.06797
SLC35F2 solute carrier family 35, member F2 -3.0112
IL32 interleukin 32 -3.00649
PPL periplakin -2.99608
LAP3 leucine aminopeptidase 3 -2.90098
ENOPH1 enolase-phosphatase 1 -2.88957
STMN1 stathmin 1 -2.8797
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.85761
RPIA ribose 5-phosphate isomerase A -2.84149
RUSC1 RUN and SH3 domain containing 1 -2.80946
TFCP2L1 transcription factor CP2-like 1 -2.80328
CCNB1 cyclin B1 -2.75834
TRIM22 tripartite motif containing 22 -2.74059
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.70973
SMG8 SMG8 nonsense mediated mRNA decay factor -2.70462
S100A8 S100 calcium binding protein A8 -2.69785
EXPH5 exophilin 5 -2.66474
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.62143
OXSR1 oxidative stress responsive 1 -2.61529
NT5DC2 5'-nucleotidase domain containing 2 -2.61463
MAB21L1 mab-21-like 1 (C. elegans) -2.60096
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.59352
SGK1 serum/glucocorticoid regulated kinase 1 -2.59319
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.58936
MTMR4 myotubularin related protein 4 -2.56533
PCCB propionyl CoA carboxylase, beta polypeptide -2.54219
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.525
DNM1 dynamin 1 -2.52238
KRT4 keratin 4, type II -2.51525
TRIM37 tripartite motif containing 37 -2.51482
ANOS1 anosmin 1 -2.49991
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.49535
SPRR1B small proline-rich protein 1B -2.49481
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.46279
DHCR24 24-dehydrocholesterol reductase -2.45812
S100A2 S100 calcium binding protein A2 -2.45533
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.44955
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.43678
S100A14 S100 calcium binding protein A14 -2.4151
BID BH3 interacting domain death agonist -2.41365
CDR2L cerebellar degeneration-related protein 2-like -2.40537
TBC1D3G TBC1 domain family member 3G -2.40436
TMX1 thioredoxin-related transmembrane protein 1 -2.40065
XPO7 exportin 7 -2.39971
KRT31 keratin 31, type I -2.39033
POMP proteasome maturation protein -2.38857
TPCN1 two pore segment channel 1 -2.37535
MT1X metallothionein 1X -2.36965
OXA1L oxidase (cytochrome c) assembly 1-like -2.36557
TYRP1 tyrosinase-related protein 1 -2.35505
NOTCH1 notch 1 -2.35425
PVALB parvalbumin -2.35005
ZNF559-ZNF177 ZNF559-ZNF177 readthrough -2.34643
NASP nuclear autoantigenic sperm protein (histone-binding) -2.34277
CAPN1 calpain 1, (mu/I) large subunit -2.33182
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.32773
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -2.32124
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.31967
FBXO34 F-box protein 34 -2.31861
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.29236
MTUS1 microtubule associated tumor suppressor 1 -2.28662
TSPAN4 tetraspanin 4 -2.28447
MAVS mitochondrial antiviral signaling protein -2.2783
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.27524
LIG4 ligase IV, DNA, ATP-dependent -2.25503
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.24328
RFC3 replication factor C (activator 1) 3, 38kDa -2.2409
ZNF227 zinc finger protein 227 -2.2288
INSIG1 insulin induced gene 1 -2.22489
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 -2.22045
VANGL1 VANGL planar cell polarity protein 1 -2.21851
ZWINT ZW10 interacting kinetochore protein -2.2145
BORA bora, aurora kinase A activator -2.19776
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.19625
NOL8 nucleolar protein 8 -2.19131
LMBR1 limb development membrane protein 1 -2.18987
IGFBP7 insulin-like growth factor binding protein 7 -2.18206
SQLE squalene epoxidase -2.18155
YTHDC1 YTH domain containing 1 -2.17793
TSC22D3 TSC22 domain family, member 3 -2.17652
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.16981
SPRR1A small proline-rich protein 1A -2.16315
ESRP2 epithelial splicing regulatory protein 2 -2.16292
HSPA8 heat shock 70kDa protein 8 -2.16152
MYL12B myosin, light chain 12B, regulatory -2.16112
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.16026
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.14686
LYPD3 LY6/PLAUR domain containing 3 -2.14568
PNPLA3 patatin-like phospholipase domain containing 3 -2.14339
GPATCH1 G patch domain containing 1 -2.12337
FAM234B family with sequence similarity 234 member B -2.11986
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.11662
CDK1 cyclin-dependent kinase 1 -2.11505
BTN3A2 butyrophilin, subfamily 3, member A2 -2.11061
ZC3H4 zinc finger CCCH-type containing 4 -2.10743
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.1074
CD47 CD47 molecule -2.09901
CDK2 cyclin-dependent kinase 2 -2.09897
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.09359
ZNF574 zinc finger protein 574 -2.09087
IQGAP1 IQ motif containing GTPase activating protein 1 -2.09064
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.08692
GLUL glutamate-ammonia ligase -2.07688
KRT6A keratin 6A, type II -2.07638
MMP7 matrix metallopeptidase 7 -2.07533
CCNC cyclin C -2.06848
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.06477
CLTB clathrin, light chain B -2.05573
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.05565
SNRPE small nuclear ribonucleoprotein polypeptide E -2.04524
ZNF146 zinc finger protein 146 -2.04504
TRIP10 thyroid hormone receptor interactor 10 -2.04176
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.02592
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -2.01665
ZNF460 zinc finger protein 460 -2.01433
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.00847
BICD2 bicaudal D homolog 2 (Drosophila) -2.00181
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.00096