CRCGN016_MCF10A.TP53.M_24H:C14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dieldrin 34.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.91956
PPARG peroxisome proliferator-activated receptor gamma 3.84782
DNMT1 DNA (cytosine-5-)-methyltransferase 1 3.39907
GPATCH8 G patch domain containing 8 2.89694
NGRN neugrin, neurite outgrowth associated 2.53782
METRN meteorin, glial cell differentiation regulator 2.44811
LOC124907782 dual specificity protein phosphatase 22 2.02968

decreased expression

Symbol Name Standardized Value
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -6.47614
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -6.01204
HMG20B high mobility group 20B -4.36888
SGK1 serum/glucocorticoid regulated kinase 1 -3.99025
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.83644
RNF167 ring finger protein 167 -3.60319
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.42744
COPS7A COP9 signalosome subunit 7A -2.9359
HSPA1A heat shock 70kDa protein 1A -2.58111
PFN1 profilin 1 -2.5757
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.46728
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.20929
ATOX1 antioxidant 1 copper chaperone -2.18743
MSN moesin -2.17429
KDM5C lysine (K)-specific demethylase 5C -2.06229
SLC35A5 solute carrier family 35, member A5 -2.02938
C1GALT1C1 C1GALT1-specific chaperone 1 -2.02776
GOLPH3L golgi phosphoprotein 3-like -2.02135