CRCGN016_MCF10A.TP53.M_24H:C15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dieldrin 11.39 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 5.45556
PRKCQ protein kinase C, theta 4.86574
CCNA1 cyclin A1 4.79242
CDCA4 cell division cycle associated 4 4.0378
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.15429
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 3.14814
IGHMBP2 immunoglobulin mu binding protein 2 2.75742
CGRRF1 cell growth regulator with ring finger domain 1 2.5787
TMEM121 transmembrane protein 121 2.43273
BMP4 bone morphogenetic protein 4 2.35895
BTK Bruton agammaglobulinemia tyrosine kinase 2.24228
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.19468
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.17263
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.14494
AMPD2 adenosine monophosphate deaminase 2 2.13649
CD300A CD300a molecule 2.08588
CD244 CD244 molecule, natural killer cell receptor 2B4 2.07957
HRC histidine rich calcium binding protein 2.06627
KISS1 KiSS-1 metastasis-suppressor 2.05246
SSX5 synovial sarcoma, X breakpoint 5 2.04605
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.03653
KRT85 keratin 85, type II 2.03648
HYI hydroxypyruvate isomerase (putative) 2.02602
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.01534

decreased expression

Symbol Name Standardized Value
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -4.71592
DNM1L dynamin 1-like -4.12264
TUBB6 tubulin, beta 6 class V -3.59384
PCCB propionyl CoA carboxylase, beta polypeptide -3.2113
ANXA2 annexin A2 -2.75752
CD9 CD9 molecule -2.56681
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.444
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.41488
RPS5 ribosomal protein S5 -2.36099
CREB1 cAMP responsive element binding protein 1 -2.32981
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.30526
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.29021
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.19246
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa -2.18892
UNC119B unc-119 homolog B (C. elegans) -2.1758
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.10259
KRT14 keratin 14, type I -2.08509
IQGAP1 IQ motif containing GTPase activating protein 1 -2.00831