CRCGN016_MCF10A.TP53.M_24H:C16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-diaminotoluene 98.95 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.62784
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.55754
TOMM34 translocase of outer mitochondrial membrane 34 4.52698
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.85819
CCDC85B coiled-coil domain containing 85B 3.37012
WIF1 WNT inhibitory factor 1 3.18934
CCNH cyclin H 2.65564
PPOX protoporphyrinogen oxidase 2.4779
COQ8A coenzyme Q8A 2.4434
COMP cartilage oligomeric matrix protein 2.37133
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.36107
ATF5 activating transcription factor 5 2.30137
MOK MOK protein kinase 2.22265
POLL polymerase (DNA directed), lambda 2.16818
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.09457
RUVBL1 RuvB-like AAA ATPase 1 2.06986
KRI1 KRI1 homolog (S. cerevisiae) 2.02901
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.02696
MAP1S microtubule-associated protein 1S 2.02325
DVL1 dishevelled segment polarity protein 1 2.0153
CHMP6 charged multivesicular body protein 6 2.00231
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.00196

decreased expression

Symbol Name Standardized Value
CIAPIN1 cytokine induced apoptosis inhibitor 1 -5.50062
ANKRD10 ankyrin repeat domain 10 -5.44279
TCTA T-cell leukemia translocation altered -5.37767
CCNB1 cyclin B1 -3.67215
KIF14 kinesin family member 14 -3.47236
KIF20A kinesin family member 20A -3.37244
UBE3C ubiquitin protein ligase E3C -3.32958
PUF60 poly-U binding splicing factor 60KDa -3.2005
LYPLA1 lysophospholipase I -3.05073
NPDC1 neural proliferation, differentiation and control, 1 -2.7384
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.66012
ZMYM2 zinc finger, MYM-type 2 -2.52681
THEM6 thioesterase superfamily member 6 -2.48889
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.41811
FNDC3B fibronectin type III domain containing 3B -2.40286
OXA1L oxidase (cytochrome c) assembly 1-like -2.3644
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -2.32082
PCNA proliferating cell nuclear antigen -2.25332
IQGAP1 IQ motif containing GTPase activating protein 1 -2.20557
KDM5D lysine (K)-specific demethylase 5D -2.18512
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.1523
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -2.10945
SOSTDC1 sclerostin domain containing 1 -2.06177
USP9Y ubiquitin specific peptidase 9, Y-linked -2.03452