CRCGN016_MCF10A.TP53.M_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-diaminotoluene 32.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EAPP E2F-associated phosphoprotein 5.46926
SPAG4 sperm associated antigen 4 5.09364
AMDHD2 amidohydrolase domain containing 2 4.78362
COMP cartilage oligomeric matrix protein 4.60146
IGHMBP2 immunoglobulin mu binding protein 2 4.51694
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.39948
KIF5C kinesin family member 5C 3.8201
FOS FBJ murine osteosarcoma viral oncogene homolog 3.64924
PRKCH protein kinase C, eta 3.49727
TRIB1 tribbles pseudokinase 1 3.43637
SPTSSA serine palmitoyltransferase, small subunit A 3.37078
ACAA1 acetyl-CoA acyltransferase 1 3.15683
HBA1 hemoglobin, alpha 1 3.091
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.79387
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.75387
PLS1 plastin 1 2.7178
PECR peroxisomal trans-2-enoyl-CoA reductase 2.68303
CCDC85B coiled-coil domain containing 85B 2.60005
MYL9 myosin, light chain 9, regulatory 2.57034
MBIP MAP3K12 binding inhibitory protein 1 2.56638
SRP54 signal recognition particle 54kDa 2.4768
CADM1 cell adhesion molecule 1 2.45142
TBL3 transducin (beta)-like 3 2.40378
MAST2 microtubule associated serine/threonine kinase 2 2.25386
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 2.24581
AAMP angio-associated, migratory cell protein 2.23248
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.23236
TPD52L2 tumor protein D52-like 2 2.17982
MGMT O-6-methylguanine-DNA methyltransferase 2.17083
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.0839
MNMIP1 manchette microtubule inner protein 1 2.08137
PQBP1 polyglutamine binding protein 1 2.0604
CD247 CD247 molecule 2.04717
DEFA3 defensin, alpha 3, neutrophil-specific 2.03859
ASL argininosuccinate lyase 2.02992
SSTR5 somatostatin receptor 5 2.02354
CNN1 calponin 1, basic, smooth muscle 2.02349
EIF6 eukaryotic translation initiation factor 6 2.01971

decreased expression

Symbol Name Standardized Value
ANXA2 annexin A2 -3.60877
ANKRD10 ankyrin repeat domain 10 -2.90568
S100A11 S100 calcium binding protein A11 -2.47303
MTERF3 mitochondrial transcription termination factor 3 -2.44081
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.39124
KDM3A lysine (K)-specific demethylase 3A -2.35871
MSN moesin -2.30035
INTS8 integrator complex subunit 8 -2.26835
IGFBP7 insulin-like growth factor binding protein 7 -2.26537
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.24306
PCCB propionyl CoA carboxylase, beta polypeptide -2.23324
WASHC4 WASH complex subunit 4 -2.16891
PLK1 polo-like kinase 1 -2.16681
PRDM4 PR domain containing 4 -2.13271
TIMP1 TIMP metallopeptidase inhibitor 1 -2.08558
GNPAT glyceronephosphate O-acyltransferase -2.07067
RAB23 RAB23, member RAS oncogene family -2.06089
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.00954