CRCGN016_MCF10A.TP53.M_24H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyphenazine 100.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

245 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 7.62755
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 7.0897
TXNRD1 thioredoxin reductase 1 6.48143
AARS1 alanyl-tRNA synthetase 1 6.06992
ALAS1 5'-aminolevulinate synthase 1 5.54138
HMOX1 heme oxygenase 1 5.43554
ASNS asparagine synthetase (glutamine-hydrolyzing) 5.32051
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 5.15902
RBKS ribokinase 5.09068
GLRX glutaredoxin (thioltransferase) 4.8087
UGDH UDP-glucose 6-dehydrogenase 4.72907
PHGDH phosphoglycerate dehydrogenase 4.71763
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.26866
MSRA methionine sulfoxide reductase A 4.2535
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 4.15678
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.9783
PYCR1 pyrroline-5-carboxylate reductase 1 3.8554
TRIB3 tribbles pseudokinase 3 3.85413
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.71602
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.71155
CAMTA2 calmodulin binding transcription activator 2 3.62368
CHMP4B charged multivesicular body protein 4B 3.61246
GPC1 glypican 1 3.50561
CTSL cathepsin L 3.39782
PSAT1 phosphoserine aminotransferase 1 3.3369
CTAGE8 CTAGE family, member 8 3.31926
TBPL1 TBP-like 1 3.24712
ABHD4 abhydrolase domain containing 4 3.19101
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.16313
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.16168
CARS1 cysteinyl-tRNA synthetase 1 3.14411
WIF1 WNT inhibitory factor 1 3.11075
YARS1 tyrosyl-tRNA synthetase 1 3.07525
INPP1 inositol polyphosphate-1-phosphatase 3.05295
XPOT exportin, tRNA 2.99777
GARS1 glycyl-tRNA synthetase 1 2.80709
HYOU1 hypoxia up-regulated 1 2.76384
STXBP1 syntaxin binding protein 1 2.7612
WARS1 tryptophanyl-tRNA synthetase 1 2.75565
VSIG2 V-set and immunoglobulin domain containing 2 2.73587
WDR7 WD repeat domain 7 2.73105
LOC128125814 uncharacterized LOC128125814 2.72615
TARS1 threonyl-tRNA synthetase 1 2.70909
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.69263
CDK7 cyclin-dependent kinase 7 2.66475
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.61234
STAMBP STAM binding protein 2.52465
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2.5134
UVRAG UV radiation resistance associated 2.50151
GTPBP2 GTP binding protein 2 2.47537
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.47525
SARS1 seryl-tRNA synthetase 1 2.46918
EPN2 epsin 2 2.46162
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.45395
NPC1 Niemann-Pick disease, type C1 2.44403
ITFG1 integrin alpha FG-GAP repeat containing 1 2.43501
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.4345
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.42426
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.42212
GALE UDP-galactose-4-epimerase 2.40114
GSK3B glycogen synthase kinase 3 beta 2.3981
INTS3 integrator complex subunit 3 2.38463
ZYX zyxin 2.3672
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.34287
ADGRG1 adhesion G protein-coupled receptor G1 2.29947
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.28756
RSF1 remodeling and spacing factor 1 2.25182
LOC102724560 cystathionine beta-synthase 2.25002
SLC67A1 solute carrier family 67 member 1 2.24149
KCTD14 potassium channel tetramerization domain containing 14 2.23957
CDPF1 cysteine-rich, DPF motif domain containing 1 2.22456
ARMCX3 armadillo repeat containing, X-linked 3 2.18766
OARD1 O-acyl-ADP-ribose deacylase 1 2.1798
AAMDC adipogenesis associated, Mth938 domain containing 2.17728
RAB4A RAB4A, member RAS oncogene family 2.17338
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.1699
ATF4 activating transcription factor 4 2.16013
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.14944
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.149
ASS1 argininosuccinate synthase 1 2.14704
SNPH syntaphilin 2.14119
GRB10 growth factor receptor-bound protein 10 2.13553
NDEL1 nudE neurodevelopment protein 1-like 1 2.13219
ZBTB35 zinc finger and BTB domain containing 35 2.11628
RAP1GAP RAP1 GTPase activating protein 2.11528
RAB3A RAB3A, member RAS oncogene family 2.11486
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 2.11035
EGR1 early growth response 1 2.10102
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.09604
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.09524
GSTZ1 glutathione S-transferase zeta 1 2.08601
TMEM39A transmembrane protein 39A 2.08491
PRSS8 protease, serine, 8 2.07847
TES testin LIM domain protein 2.07201
MON1B MON1 secretory trafficking family member B 2.06955
MYH9 myosin, heavy chain 9, non-muscle 2.06319
NECAB3 N-terminal EF-hand calcium binding protein 3 2.0604
NUCB2 nucleobindin 2 2.06001
INHBE inhibin, beta E 2.05582
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.04077
TUFT1 tuftelin 1 2.03919
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.0378
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 2.03676
SH3BP4 SH3-domain binding protein 4 2.0327
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 2.02937
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.02721
ANKRD11 ankyrin repeat domain 11 2.02146
ELMO3 engulfment and cell motility 3 2.01934
COPG1 coatomer protein complex, subunit gamma 1 2.01001

decreased expression

Symbol Name Standardized Value
CDK4 cyclin-dependent kinase 4 -6.15842
CDC45 cell division cycle 45 -5.87431
STMN1 stathmin 1 -4.94687
RFC2 replication factor C (activator 1) 2, 40kDa -4.66014
HOXA5 homeobox A5 -4.57793
MCM3 minichromosome maintenance complex component 3 -4.45995
PCNA proliferating cell nuclear antigen -4.4047
HSPA8 heat shock 70kDa protein 8 -4.33692
CCNB1 cyclin B1 -4.08358
TUBB6 tubulin, beta 6 class V -3.99985
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.85641
ZDHHC6 zinc finger, DHHC-type containing 6 -3.84312
NUP85 nucleoporin 85kDa -3.56418
BIRC5 baculoviral IAP repeat containing 5 -3.46984
KIF20A kinesin family member 20A -3.45683
TNIP1 TNFAIP3 interacting protein 1 -3.4384
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.40397
ELAC2 elaC ribonuclease Z 2 -3.39189
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.35492
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.32486
PSRC1 proline/serine-rich coiled-coil 1 -3.30367
NT5DC2 5'-nucleotidase domain containing 2 -3.2952
PIH1D1 PIH1 domain containing 1 -3.24886
HSPA1A heat shock 70kDa protein 1A -3.23467
POLR1G RNA polymerase I subunit G -3.15404
MCM10 minichromosome maintenance complex component 10 -3.13529
GINS3 GINS complex subunit 3 (Psf3 homolog) -3.09095
PARP1 poly (ADP-ribose) polymerase 1 -3.07941
CDC6 cell division cycle 6 -3.06651
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.00268
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.9857
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.96074
NUSAP1 nucleolar and spindle associated protein 1 -2.94402
GRWD1 glutamate-rich WD repeat containing 1 -2.88716
DDB2 damage-specific DNA binding protein 2, 48kDa -2.81778
AURKB aurora kinase B -2.81651
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.81442
THAP11 THAP domain containing 11 -2.80385
MCM6 minichromosome maintenance complex component 6 -2.80042
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.76795
GATA4 GATA binding protein 4 -2.75119
DHFR dihydrofolate reductase -2.71257
WDR76 WD repeat domain 76 -2.69371
MCM7 minichromosome maintenance complex component 7 -2.64781
ZNF274 zinc finger protein 274 -2.64243
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.61934
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.6
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.5742
JPT2 Jupiter microtubule associated homolog 2 -2.56859
PLK1 polo-like kinase 1 -2.55488
CCNA2 cyclin A2 -2.55461
ASF1B anti-silencing function 1B histone chaperone -2.54539
FEN1 flap structure-specific endonuclease 1 -2.54027
CCNF cyclin F -2.52766
AURKA aurora kinase A -2.51848
HOXA4 homeobox A4 -2.49991
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.48064
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.46308
MRPS16 mitochondrial ribosomal protein S16 -2.45726
CDCA4 cell division cycle associated 4 -2.45188
FPGS folylpolyglutamate synthase -2.44082
SPC25 SPC25, NDC80 kinetochore complex component -2.43724
NUP93 nucleoporin 93kDa -2.42095
S100A3 S100 calcium binding protein A3 -2.39029
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -2.38951
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.37911
RFC3 replication factor C (activator 1) 3, 38kDa -2.36561
DCK deoxycytidine kinase -2.36505
HAT1 histone acetyltransferase 1 -2.35477
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.34876
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -2.34223
IL13RA2 interleukin 13 receptor, alpha 2 -2.34021
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.33899
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.33234
KIF11 kinesin family member 11 -2.3263
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.31869
ELP5 elongator acetyltransferase complex subunit 5 -2.30751
PRPF31 pre-mRNA processing factor 31 -2.30454
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.29457
NASP nuclear autoantigenic sperm protein (histone-binding) -2.28668
KCTD20 potassium channel tetramerization domain containing 20 -2.28182
TRIP13 thyroid hormone receptor interactor 13 -2.27869
UFM1 ubiquitin-fold modifier 1 -2.27829
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.27238
SRSF2 serine/arginine-rich splicing factor 2 -2.27222
DSN1 DSN1, MIS12 kinetochore complex component -2.26977
CHEK1 checkpoint kinase 1 -2.2642
PSMC3IP PSMC3 interacting protein -2.26412
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.25293
FASTKD5 FAST kinase domains 5 -2.25032
PRKD3 protein kinase D3 -2.24169
TPX2 TPX2, microtubule-associated -2.23739
SMNDC1 survival motor neuron domain containing 1 -2.22983
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.22401
ANAPC15 anaphase promoting complex subunit 15 -2.19455
TUBA1B tubulin, alpha 1b -2.19367
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.19304
CDCA3 cell division cycle associated 3 -2.1854
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.18341
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -2.17703
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.17698
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.17384
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.17155
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.17067
RPP30 ribonuclease P/MRP 30kDa subunit -2.16525
RFWD3 ring finger and WD repeat domain 3 -2.15616
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.15085
EXO1 exonuclease 1 -2.14562
DBF4 DBF4 zinc finger -2.14507
MCMBP minichromosome maintenance complex binding protein -2.13631
DCLRE1B DNA cross-link repair 1B -2.12941
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.12458
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -2.12238
MRPS17 mitochondrial ribosomal protein S17 -2.11903
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.11266
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.11166
ANGPTL7 angiopoietin-like 7 -2.10174
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -2.10113
TMEM51 transmembrane protein 51 -2.10004
CENPA centromere protein A -2.09626
MCM4 minichromosome maintenance complex component 4 -2.09579
ZNF324 zinc finger protein 324 -2.07505
MCM5 minichromosome maintenance complex component 5 -2.07388
PGRMC1 progesterone receptor membrane component 1 -2.06973
RPP25 ribonuclease P/MRP 25kDa subunit -2.0672
TMPO thymopoietin -2.05768
OIP5 Opa interacting protein 5 -2.04602
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.04297
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.04116
TSPAN3 tetraspanin 3 -2.03522
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -2.02502
CLTA clathrin, light chain A -2.02052
RBL1 retinoblastoma-like 1 -2.01717
RAD51 RAD51 recombinase -2.01194
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.01191
ART3 ADP-ribosyltransferase 3 -2.0117