CRCGN016_MCF10A.TP53.M_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyphenazine 33.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

125 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALAS1 5'-aminolevulinate synthase 1 5.66297
HLA-DRA major histocompatibility complex, class II, DR alpha 4.24992
TCEA2 transcription elongation factor A (SII), 2 4.11937
CRELD2 cysteine-rich with EGF-like domains 2 4.01913
GARRE1 granule associated Rac and RHOG effector 1 3.68101
BAMBI BMP and activin membrane-bound inhibitor 3.39744
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.38298
FGFR4 fibroblast growth factor receptor 4 3.37433
MSRA methionine sulfoxide reductase A 3.18744
CCDC85B coiled-coil domain containing 85B 3.14856
TXNRD1 thioredoxin reductase 1 2.98351
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.8512
NIT1 nitrilase 1 2.81961
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.77696
TKFC triokinase/FMN cyclase 2.72564
DDTL D-dopachrome tautomerase-like 2.57782
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.56776
DGCR6L DiGeorge syndrome critical region gene 6-like 2.51336
MAN2C1 mannosidase, alpha, class 2C, member 1 2.51017
MMP2 matrix metallopeptidase 2 2.44985
H2BC21 H2B clustered histone 21 2.44327
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.42016
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.39315
MINDY1 MINDY lysine 48 deubiquitinase 1 2.35167
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.33023
ANAPC2 anaphase promoting complex subunit 2 2.321
TMEM53 transmembrane protein 53 2.31585
PON3 paraoxonase 3 2.31281
WIF1 WNT inhibitory factor 1 2.29857
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.27977
CERK ceramide kinase 2.27443
TOP3B topoisomerase (DNA) III beta 2.25867
PRSS8 protease, serine, 8 2.25862
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.25839
H2AC19 H2A clustered histone 19 2.2552
THAP7 THAP domain containing 7 2.24672
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 2.22424
DCAF11 DDB1 and CUL4 associated factor 11 2.21469
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.21438
GSTA1 glutathione S-transferase alpha 1 2.20927
GSDMB gasdermin B 2.1926
ZBTB48 zinc finger and BTB domain containing 48 2.18916
MPST mercaptopyruvate sulfurtransferase 2.1688
MED15 mediator complex subunit 15 2.14601
GTPBP2 GTP binding protein 2 2.14595
YPEL1 yippee-like 1 (Drosophila) 2.13462
SKIC8 SKI8 subunit of superkiller complex 2.12832
IRF6 interferon regulatory factor 6 2.10866
CIAO3 cytosolic iron-sulfur assembly component 3 2.10859
ACAA1 acetyl-CoA acyltransferase 1 2.10688
KLHDC2 kelch domain containing 2 2.10241
WBP2 WW domain binding protein 2 2.08991
WDR73 WD repeat domain 73 2.07912
PRODH proline dehydrogenase (oxidase) 1 2.07544
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.0681
CREB3L4 cAMP responsive element binding protein 3-like 4 2.06625
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.06166
WASHC5 WASH complex subunit 5 2.06054
TMEM265 transmembrane protein 265 2.05513
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.05279
DCAF10 DDB1 and CUL4 associated factor 10 2.05177
RNF115 ring finger protein 115 2.04896
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.04399
PPOX protoporphyrinogen oxidase 2.04282
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.04279
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.03919
HMOX1 heme oxygenase 1 2.034
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.03384
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.02711
CHMP4B charged multivesicular body protein 4B 2.02599
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 2.02291
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.01627
ASL argininosuccinate lyase 2.01528
TMEM254 transmembrane protein 254 2.0147
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.00022

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.05865
ANKRD10 ankyrin repeat domain 10 -4.67089
THAP11 THAP domain containing 11 -4.36496
AURKA aurora kinase A -3.80204
DNM1L dynamin 1-like -3.79222
CDC20 cell division cycle 20 -3.7825
HSPA1A heat shock 70kDa protein 1A -3.51469
KIF20A kinesin family member 20A -3.39723
KIF14 kinesin family member 14 -2.91485
TRAPPC3 trafficking protein particle complex 3 -2.90074
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.89212
PLK1 polo-like kinase 1 -2.8125
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.80128
TUBB6 tubulin, beta 6 class V -2.7432
SLC35F2 solute carrier family 35, member F2 -2.66995
MEAF6 MYST/Esa1-associated factor 6 -2.6535
MCM3 minichromosome maintenance complex component 3 -2.65328
TSPAN3 tetraspanin 3 -2.59827
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.54304
STMN1 stathmin 1 -2.51927
CDCA4 cell division cycle associated 4 -2.46254
CAB39 calcium binding protein 39 -2.46045
NOP56 NOP56 ribonucleoprotein -2.419
LDHA lactate dehydrogenase A -2.40798
CCNB2 cyclin B2 -2.40162
HOXA5 homeobox A5 -2.40059
TPX2 TPX2, microtubule-associated -2.36471
CRY1 cryptochrome circadian clock 1 -2.33366
DSG2 desmoglein 2 -2.32627
TOP2A topoisomerase (DNA) II alpha 170kDa -2.30672
TLK1 tousled-like kinase 1 -2.25681
FASTKD5 FAST kinase domains 5 -2.24917
TCERG1 transcription elongation regulator 1 -2.17635
LOC112694756 uncharaterized LOC112694756 -2.17355
ELAVL1 ELAV like RNA binding protein 1 -2.16517
CDK6 cyclin-dependent kinase 6 -2.15187
TIMP1 TIMP metallopeptidase inhibitor 1 -2.11443
FHL2 four and a half LIM domains 2 -2.1008
COL4A1 collagen, type IV, alpha 1 -2.09892
PYGL phosphorylase, glycogen, liver -2.09701
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.09314
NOSIP nitric oxide synthase interacting protein -2.07817
RESF1 retroelement silencing factor 1 -2.07756
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.07066
TMEM185B transmembrane protein 185B -2.06883
NCK2 NCK adaptor protein 2 -2.06686
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.06416
SNX5 sorting nexin 5 -2.03457
OSMR oncostatin M receptor -2.03347
OXA1L oxidase (cytochrome c) assembly 1-like -2.00585