CRCGN016_MCF10A.TP53.M_24H:D03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyphenazine 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

117 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.66836
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.36143
ZNF589 zinc finger protein 589 3.05546
ZFYVE26 zinc finger, FYVE domain containing 26 2.76443
PRR15L proline rich 15-like 2.74491
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.73991
ABHD4 abhydrolase domain containing 4 2.69512
ARMCX1 armadillo repeat containing, X-linked 1 2.6943
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.65053
STAT4 signal transducer and activator of transcription 4 2.64576
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.64115
TMLHE trimethyllysine hydroxylase, epsilon 2.61629
INHBB inhibin, beta B 2.59927
GSDMB gasdermin B 2.54097
STON1 stonin 1 2.50064
ALAS1 5'-aminolevulinate synthase 1 2.49729
CCL1 chemokine (C-C motif) ligand 1 2.4735
BRD9 bromodomain containing 9 2.47172
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.41833
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.41186
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.38251
ZMYM3 zinc finger, MYM-type 3 2.36067
ARMCX4 armadillo repeat containing, X-linked 4 2.34214
CUX2 cut-like homeobox 2 2.33416
MMP2 matrix metallopeptidase 2 2.27698
RBM15B RNA binding motif protein 15B 2.27287
NCF2 neutrophil cytosolic factor 2 2.27222
MRAS muscle RAS oncogene homolog 2.25691
MOB3B MOB kinase activator 3B 2.25317
DHCR24 24-dehydrocholesterol reductase 2.24667
TESK1 testis-specific kinase 1 2.23749
SCRN3 secernin 3 2.21999
TMC6 transmembrane channel-like 6 2.21854
SEC31B SEC31 homolog B (S. cerevisiae) 2.20979
EDC3 enhancer of mRNA decapping 3 2.20821
DNAH17 dynein, axonemal, heavy chain 17 2.20509
ZNF232 zinc finger protein 232 2.20354
CORO1A coronin, actin binding protein, 1A 2.19746
PCDHA9 protocadherin alpha 9 2.1862
MOSPD1 motile sperm domain containing 1 2.16926
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.1469
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.13699
ACTL8 actin-like 8 2.13612
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.13249
ANO2 anoctamin 2, calcium activated chloride channel 2.12792
H2AP H2A.P histone 2.12361
CLEC10A C-type lectin domain family 10, member A 2.11637
GPATCH2L G patch domain containing 2-like 2.10994
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.10365
SLC49A3 solute carrier family 49 member 3 2.09891
ANKRD55 ankyrin repeat domain 55 2.09828
RAI14 retinoic acid induced 14 2.09767
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 2.09765
CRYBA2 crystallin, beta A2 2.09732
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.09597
FCRLB Fc receptor-like B 2.09565
CIAO3 cytosolic iron-sulfur assembly component 3 2.09302
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.08696
MEP1B meprin A, beta 2.08461
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 2.07839
TTC13 tetratricopeptide repeat domain 13 2.07527
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.06921
NIT1 nitrilase 1 2.06506
HSPA12A heat shock 70kDa protein 12A 2.06344
SOCS4 suppressor of cytokine signaling 4 2.06129
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.05772
CDKL3 cyclin-dependent kinase-like 3 2.05682
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.05639
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.0558
KLHL4 kelch-like family member 4 2.05333
FGF21 fibroblast growth factor 21 2.0533
TBCC tubulin folding cofactor C 2.04579
PCDH8 protocadherin 8 2.04514
GRM6 glutamate receptor, metabotropic 6 2.04392
SYNGR4 synaptogyrin 4 2.03999
IPO13 importin 13 2.03902
KLHL12 kelch-like family member 12 2.03263
CCRL2 chemokine (C-C motif) receptor-like 2 2.03049
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.029
CALCRL calcitonin receptor-like 2.02489
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.02151
PARP11 poly (ADP-ribose) polymerase family, member 11 2.02051
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.00986
ZFP37 ZFP37 zinc finger protein 2.00749
PKDREJ polycystin (PKD) family receptor for egg jelly 2.00733
LTA lymphotoxin alpha 2.00711
ACE angiotensin I converting enzyme 2.00699
GK2 glycerol kinase 2 2.00435
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.00142
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.00093
FKBPL FK506 binding protein like 2.00052
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.00029

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -4.87749
COTL1 coactosin-like F-actin binding protein 1 -4.51285
CCDC86 coiled-coil domain containing 86 -3.69375
TM9SF3 transmembrane 9 superfamily member 3 -3.35266
PMM2 phosphomannomutase 2 -3.16075
OXSR1 oxidative stress responsive 1 -2.60901
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.51578
REEP5 receptor accessory protein 5 -2.36638
KIF14 kinesin family member 14 -2.315
MT1X metallothionein 1X -2.31328
HLTF helicase-like transcription factor -2.31063
TSPAN3 tetraspanin 3 -2.2851
MACROD1 MACRO domain containing 1 -2.27495
CDC20 cell division cycle 20 -2.25665
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.23098
HMG20B high mobility group 20B -2.21512
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.19557
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.18587
CRTAP cartilage associated protein -2.18445
CREG1 cellular repressor of E1A-stimulated genes 1 -2.16245
GLOD4 glyoxalase domain containing 4 -2.09793
TMEM109 transmembrane protein 109 -2.06485
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.04846
URGCP upregulator of cell proliferation -2.04389
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.00496