CRCGN016_MCF10A.TP53.M_24H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nTZDpa 5.56 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 7.12195
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.98428
UBQLN2 ubiquilin 2 4.76652
CARMIL1 capping protein regulator and myosin 1 linker 1 4.50677
STAMBP STAM binding protein 3.77228
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.29013
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.82597
LYRM1 LYR motif containing 1 2.7364
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.61664
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.54013
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.33537
TLCD3A TLC domain containing 3A 2.28243
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0692
PHGDH phosphoglycerate dehydrogenase 2.04185

decreased expression

Symbol Name Standardized Value
TRAPPC3 trafficking protein particle complex 3 -5.83434
HMG20B high mobility group 20B -4.87742
BASP1 brain abundant, membrane attached signal protein 1 -3.99239
REEP5 receptor accessory protein 5 -3.42755
HSPA1A heat shock 70kDa protein 1A -3.04901
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.82723
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.74634
CBR3 carbonyl reductase 3 -2.6952
MEAF6 MYST/Esa1-associated factor 6 -2.6792
MRPS15 mitochondrial ribosomal protein S15 -2.57261
ZMYM4 zinc finger, MYM-type 4 -2.35115
CORO1A coronin, actin binding protein, 1A -2.32635
TRAPPC6A trafficking protein particle complex 6A -2.23295
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.22296
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.12999
S100PBP S100P binding protein -2.11324
SEC31B SEC31 homolog B (S. cerevisiae) -2.10966
RNF146 ring finger protein 146 -2.1092
AGO1 argonaute RISC catalytic component 1 -2.10239
MAP7D1 MAP7 domain containing 1 -2.08203
SNIP1 Smad nuclear interacting protein 1 -2.01102
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.00921