CRCGN016_MCF10A.TP53.M_24H:D08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tributyltin 0.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 6.06475
TCEA2 transcription elongation factor A (SII), 2 4.61671
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.92215
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.9102
CETN3 centrin, EF-hand protein, 3 3.70299
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.70012
IL1B interleukin 1, beta 3.38628
E2F2 E2F transcription factor 2 3.13507
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.03258
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.84094
EPN2 epsin 2 2.74618
BOLA1 bolA family member 1 2.74343
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.74332
IL4R interleukin 4 receptor 2.71864
ETFB electron-transfer-flavoprotein, beta polypeptide 2.55887
NOTCH1 notch 1 2.43703
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.41771
FHL2 four and a half LIM domains 2 2.41059
COMP cartilage oligomeric matrix protein 2.38063
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.36975
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.33527
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.31482
NLRP4 NLR family, pyrin domain containing 4 2.28156
HOXD10 homeobox D10 2.24822
PNKP polynucleotide kinase 3'-phosphatase 2.24772
ABHD6 abhydrolase domain containing 6 2.2455
ECH1 enoyl CoA hydratase 1, peroxisomal 2.24295
NUCB2 nucleobindin 2 2.23852
DLL3 delta-like 3 (Drosophila) 2.22258
IL24 interleukin 24 2.22134
CNPY3 canopy FGF signaling regulator 3 2.19695
BPHL biphenyl hydrolase-like (serine hydrolase) 2.17193
MRPL37 mitochondrial ribosomal protein L37 2.16704
PDCD10 programmed cell death 10 2.14081
ECI2 enoyl-CoA delta isomerase 2 2.13725
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.12949
TROAP trophinin associated protein 2.08395
TOMM34 translocase of outer mitochondrial membrane 34 2.06563
FGD1 FYVE, RhoGEF and PH domain containing 1 2.06319
GALE UDP-galactose-4-epimerase 2.05451
HGFAC HGF activator 2.03224
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.00501

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.17493
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.85491
GRWD1 glutamate-rich WD repeat containing 1 -4.16351
ANKRD10 ankyrin repeat domain 10 -3.80982
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.36796
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.20054
CEMIP2 cell migration inducing hyaluronidase 2 -3.05502
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.829
INSIG1 insulin induced gene 1 -2.81918
S100A4 S100 calcium binding protein A4 -2.77029
RGS2 regulator of G-protein signaling 2 -2.65879
SOAT2 sterol O-acyltransferase 2 -2.52327
SQLE squalene epoxidase -2.36729
MVD mevalonate (diphospho) decarboxylase -2.2575
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.25717
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.15191
ACLY ATP citrate lyase -2.09121
TCTA T-cell leukemia translocation altered -2.08121
LPIN1 lipin 1 -2.05973
LIG4 ligase IV, DNA, ATP-dependent -2.05887
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.05882
CREB1 cAMP responsive element binding protein 1 -2.05063
UTRN utrophin -2.01512