CRCGN016_MCF10A.TP53.M_24H:D09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tributyltin 0.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCEA2 transcription elongation factor A (SII), 2 5.96076
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.60121
CARMIL1 capping protein regulator and myosin 1 linker 1 3.96749
HBA1 hemoglobin, alpha 1 3.6416
PPOX protoporphyrinogen oxidase 2.82628
ACAA1 acetyl-CoA acyltransferase 1 2.80806
TCTN1 tectonic family member 1 2.6439
COMP cartilage oligomeric matrix protein 2.52179
GINS1 GINS complex subunit 1 (Psf1 homolog) 2.40872
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.29023
HBB hemoglobin, beta 2.28333
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.246
DYNLT1 dynein, light chain, Tctex-type 1 2.15748
RBM38 RNA binding motif protein 38 2.12851
TPD52L1 tumor protein D52-like 1 2.05675
WIF1 WNT inhibitory factor 1 2.04984
ADAT1 adenosine deaminase, tRNA-specific 1 2.04763
CHN1 chimerin 1 2.00008

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.88652
BASP1 brain abundant, membrane attached signal protein 1 -4.60157
SLC25A46 solute carrier family 25, member 46 -4.49666
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.43279
UFM1 ubiquitin-fold modifier 1 -4.12982
CHMP4B charged multivesicular body protein 4B -4.07336
SH3D19 SH3 domain containing 19 -3.44517
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.19379
SORBS3 sorbin and SH3 domain containing 3 -3.05434
TEX10 testis expressed 10 -3.04097
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.00995
SGK1 serum/glucocorticoid regulated kinase 1 -2.85113
MT1X metallothionein 1X -2.79641
KDM3A lysine (K)-specific demethylase 3A -2.76793
GOLT1B golgi transport 1B -2.67722
MSN moesin -2.58959
PIH1D1 PIH1 domain containing 1 -2.45071
PROSER1 proline and serine rich 1 -2.38163
TIMP1 TIMP metallopeptidase inhibitor 1 -2.25098
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.24327
TSPAN3 tetraspanin 3 -2.15237
PITPNA phosphatidylinositol transfer protein, alpha -2.14287
MRPS2 mitochondrial ribosomal protein S2 -2.13817
SOCS6 suppressor of cytokine signaling 6 -2.13779
TOR4A torsin family 4, member A -2.11728
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.02526
HMG20B high mobility group 20B -2.02394
TSC22D1 TSC22 domain family, member 1 -2.02242
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.01467
SOWAHC sosondowah ankyrin repeat domain family member C -2.0108
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) -2.00361
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.00106