CRCGN016_MCF10A.TP53.M_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description rosi with tphp perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 4.77404
STAMBP STAM binding protein 4.2761
GPATCH8 G patch domain containing 8 3.38592
DENND2D DENN/MADD domain containing 2D 3.06527
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 3.0169
DPH2 DPH2 homolog (S. cerevisiae) 3.00844
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.00005
SCYL3 SCY1-like 3 (S. cerevisiae) 2.37412
ZBED5 zinc finger, BED-type containing 5 2.32449
SESN1 sestrin 1 2.28034
BACE2 beta-site APP-cleaving enzyme 2 2.27913
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.27197
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.21405
PUM1 pumilio RNA-binding family member 1 2.20209
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.16467
SKIC2 SKI2 subunit of superkiller complex 2.15916
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.12245
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.06998
TSNAX translin-associated factor X 2.04358
ZW10 zw10 kinetochore protein 2.035

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -5.54761
STXBP2 syntaxin binding protein 2 -4.95956
COTL1 coactosin-like F-actin binding protein 1 -4.7721
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.69538
TCTA T-cell leukemia translocation altered -4.49673
YME1L1 YME1-like 1 ATPase -4.38202
NLRP4 NLR family, pyrin domain containing 4 -4.2213
HMG20B high mobility group 20B -3.81603
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.53632
SGK1 serum/glucocorticoid regulated kinase 1 -3.50732
SCYL2 SCY1-like 2 (S. cerevisiae) -3.39728
KITLG KIT ligand -2.93267
FPGS folylpolyglutamate synthase -2.85391
LMAN1 lectin, mannose-binding, 1 -2.67844
KDM3A lysine (K)-specific demethylase 3A -2.66103
DAND5 DAN domain family member 5, BMP antagonist -2.63984
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.63544
PIH1D1 PIH1 domain containing 1 -2.50037
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.46963
FRS2 fibroblast growth factor receptor substrate 2 -2.41406
KCTD20 potassium channel tetramerization domain containing 20 -2.37962
EXOC5 exocyst complex component 5 -2.36594
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.28112
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.26722
WAC WW domain containing adaptor with coiled-coil -2.25009
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.2497
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.2177
MAPK1 mitogen-activated protein kinase 1 -2.1737
AFF4 AF4/FMR2 family, member 4 -2.15279
COG7 component of oligomeric golgi complex 7 -2.11638
ABHD17B abhydrolase domain containing 17B -2.10127
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.1002
RGPD2 RANBP2-like and GRIP domain containing 2 -2.07119
CLIC4 chloride intracellular channel 4 -2.04758
AGPS alkylglycerone phosphate synthase -2.04533
BAX BCL2-associated X protein -2.03618
RASAL2 RAS protein activator like 2 -2.0258
RCAN3 RCAN family member 3 -2.02495
IQGAP1 IQ motif containing GTPase activating protein 1 -2.02031