CRCGN016_MCF10A.TP53.M_24H:D12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description rosi with tphp perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VAV3 vav 3 guanine nucleotide exchange factor 5.10418
EPHB2 EPH receptor B2 4.75698
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 4.18175
PRKCQ protein kinase C, theta 3.57714
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.83164
KDM5D lysine (K)-specific demethylase 5D 2.71952
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.67583
GPR20 G protein-coupled receptor 20 2.58844
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.51731
GLI2 GLI family zinc finger 2 2.46554
SMIM40 small integral membrane protein 40 2.37938
TNNT1 troponin T type 1 (skeletal, slow) 2.3274
USP9Y ubiquitin specific peptidase 9, Y-linked 2.3082
HTATSF1 HIV-1 Tat specific factor 1 2.30251
GLI1 GLI family zinc finger 1 2.29503
TLR4 toll-like receptor 4 2.26039
CHODL chondrolectin 2.24075
KIF5C kinesin family member 5C 2.22411
MMP1 matrix metallopeptidase 1 2.22169
LSM1 LSM1, U6 small nuclear RNA associated 2.18237
MYOZ3 myozenin 3 2.16722
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 2.16067
ZNF148 zinc finger protein 148 2.14956
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.13866
MTA2 metastasis associated 1 family, member 2 2.13634
IL17RA interleukin 17 receptor A 2.1358
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.10355
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.09363
KRT85 keratin 85, type II 2.09214
SLC38A12 solute carrier family 38 member 12 2.05335
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.04614
RPAP2 RNA polymerase II associated protein 2 2.03705
TPSG1 tryptase gamma 1 2.03374
CEPT1 choline/ethanolamine phosphotransferase 1 2.03091
BNC2 basonuclin 2 2.02974
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 2.02413
GDF9 growth differentiation factor 9 2.00432
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.00035

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -6.7828
MAPK13 mitogen-activated protein kinase 13 -5.77134
KRT14 keratin 14, type I -5.0
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.8067
PFN1 profilin 1 -4.41771
PRPF4 pre-mRNA processing factor 4 -3.97471
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.70705
ANKRD10 ankyrin repeat domain 10 -3.62209
ENTR1 endosome associated trafficking regulator 1 -3.52401
COTL1 coactosin-like F-actin binding protein 1 -3.52275
SLC25A46 solute carrier family 25, member 46 -3.38048
OXA1L oxidase (cytochrome c) assembly 1-like -3.29961
PAEP progestagen-associated endometrial protein -3.06114
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -3.03541
SEC16A SEC16 homolog A (S. cerevisiae) -3.03007
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.95497
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.89626
BASP1 brain abundant, membrane attached signal protein 1 -2.82158
PRRC2B proline-rich coiled-coil 2B -2.78708
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.77447
PHB2 prohibitin 2 -2.72946
PPP6C protein phosphatase 6, catalytic subunit -2.66652
TUBB4B tubulin, beta 4B class IVb -2.66509
NELFB negative elongation factor complex member B -2.59595
REXO2 RNA exonuclease 2 -2.57714
RPL35 ribosomal protein L35 -2.54123
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.53735
COQ4 coenzyme Q4 -2.48834
SMC1A structural maintenance of chromosomes 1A -2.48398
PMPCA peptidase (mitochondrial processing) alpha -2.48373
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.39846
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.36652
ANAPC2 anaphase promoting complex subunit 2 -2.2972
PCNA proliferating cell nuclear antigen -2.2185
EDF1 endothelial differentiation-related factor 1 -2.1814
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.16912
PTPRM protein tyrosine phosphatase, receptor type, M -2.16753
SRFBP1 serum response factor binding protein 1 -2.16149
NPDC1 neural proliferation, differentiation and control, 1 -2.15904
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.13365
UBAC1 UBA domain containing 1 -2.12548
TIMCC TIM double twin CX3C motif chaperone -2.12392
PEF1 penta-EF-hand domain containing 1 -2.07111
MAEA macrophage erythroblast attacher -2.055
DDA1 DET1 and DDB1 associated 1 -2.03821
ARF1 ADP-ribosylation factor 1 -2.03494
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.02934
ZNF266 zinc finger protein 266 -2.01885
MED27 mediator complex subunit 27 -2.01743
ASTN2 astrotactin 2 -2.00591
GOLT1B golgi transport 1B -2.00485