CRCGN016_MCF10A.TP53.M_24H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trichlorophenoxyacetic acid 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LAGE3 L antigen family, member 3 4.82913
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.1171
ADGRE5 adhesion G protein-coupled receptor E5 3.07078
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.04062
ALDOC aldolase C, fructose-bisphosphate 2.9652
HBB hemoglobin, beta 2.80977
HMOX1 heme oxygenase 1 2.48743
EGR1 early growth response 1 2.46228
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.40979
CARMIL1 capping protein regulator and myosin 1 linker 1 2.35126
GALE UDP-galactose-4-epimerase 2.31087
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.27257
FAM3A family with sequence similarity 3, member A 2.25551
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.23191
ZNF586 zinc finger protein 586 2.21891
HBA1 hemoglobin, alpha 1 2.19036
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.16213
HMGA2 high mobility group AT-hook 2 2.11081
SLC10A3 solute carrier family 10, member 3 2.09884

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -4.08117
MAPK13 mitogen-activated protein kinase 13 -3.96796
TCEA2 transcription elongation factor A (SII), 2 -3.44292
CCNB1 cyclin B1 -3.34584
TUBB6 tubulin, beta 6 class V -3.0865
PGAM4 phosphoglycerate mutase family member 4 -3.01097
TXNRD1 thioredoxin reductase 1 -2.81203
BASP1 brain abundant, membrane attached signal protein 1 -2.64631
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.51859
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.39382
FKBP1C FK506 binding protein 1C -2.27224
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.22225
PANK2 pantothenate kinase 2 -2.20298
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) -2.11115
HHEX hematopoietically expressed homeobox -2.10032
GCLM glutamate-cysteine ligase, modifier subunit -2.0958
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.08211
ANXA2 annexin A2 -2.05848
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.04525
KIF11 kinesin family member 11 -2.01217