CRCGN016_MCF10A.TP53.M_24H:D14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,5-trichlorophenoxyacetic acid 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.51237
PEX11A peroxisomal biogenesis factor 11 alpha 4.89844
FGFR4 fibroblast growth factor receptor 4 4.29062
E2F2 E2F transcription factor 2 4.25237
STIMATE STIM activating enhancer 4.04281
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.9703
HBA1 hemoglobin, alpha 1 3.91463
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 3.88711
GATD3 glutamine amidotransferase class 1 domain containing 3 3.53526
PFKL phosphofructokinase, liver 3.5114
CNRIP1 cannabinoid receptor interacting protein 1 3.29857
CCDC92 coiled-coil domain containing 92 3.14158
EML3 echinoderm microtubule associated protein like 3 3.08837
GET1 guided entry of tail-anchored proteins factor 1 2.99175
ACAA1 acetyl-CoA acyltransferase 1 2.97935
INTS3 integrator complex subunit 3 2.88705
TRAK2 trafficking protein, kinesin binding 2 2.73859
COMP cartilage oligomeric matrix protein 2.71521
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.61911
UBQLN2 ubiquilin 2 2.45241
TRAPPC10 trafficking protein particle complex 10 2.42902
SNX11 sorting nexin 11 2.42642
SERF1A small EDRK-rich factor 1A (telomeric) 2.41305
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.36785
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.3638
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.3633
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.35136
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.34707
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.33784
REEP1 receptor accessory protein 1 2.2503
LAG3 lymphocyte-activation gene 3 2.19503
RWDD2B RWD domain containing 2B 2.17925
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.17863
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.16132
HBB hemoglobin, beta 2.12743
SH3BP2 SH3-domain binding protein 2 2.11316
ERI3 ERI1 exoribonuclease family member 3 2.01377

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -6.76431
WASHC4 WASH complex subunit 4 -3.96061
MT1X metallothionein 1X -3.59943
MAPK13 mitogen-activated protein kinase 13 -3.4544
MREG melanoregulin -3.0007
BASP1 brain abundant, membrane attached signal protein 1 -2.95954
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -2.89053
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -2.87609
CD81 CD81 molecule -2.86927
CCDC86 coiled-coil domain containing 86 -2.63884
ABT1 activator of basal transcription 1 -2.55555
CAVIN3 caveolae associated protein 3 -2.50016
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.48258
FCMR Fc fragment of IgM receptor -2.4819
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.46573
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.2529
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.24843
GDF15 growth differentiation factor 15 -2.24774
OSBPL8 oxysterol binding protein-like 8 -2.23941
CALB2 calbindin 2 -2.22084
RUBCNL rubicon like autophagy enhancer -2.12133
ZNF750 zinc finger protein 750 -2.09427
CRABP2 cellular retinoic acid binding protein 2 -2.08316
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.0794
HAL histidine ammonia-lyase -2.07484
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 -2.04094
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.03591
TBC1D15 TBC1 domain family, member 15 -2.02987
CA14 carbonic anhydrase XIV -2.01764