CRCGN016_MCF10A.TP53.M_24H:D16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-ethyl-2-hexenal 99.96 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 4.88575
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.52436
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.35404
SNAP25 synaptosomal-associated protein, 25kDa 4.12878
KDM5D lysine (K)-specific demethylase 5D 3.9355
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.57258
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.55558
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.08787
TIAM1 T-cell lymphoma invasion and metastasis 1 2.95637
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.57726
PKN1 protein kinase N1 2.42998
USP9Y ubiquitin specific peptidase 9, Y-linked 2.32527
MGST3 microsomal glutathione S-transferase 3 2.25788
IFITM1 interferon induced transmembrane protein 1 2.24891
MELK maternal embryonic leucine zipper kinase 2.21596
ZNF451 zinc finger protein 451 2.2127
RLIM ring finger protein, LIM domain interacting 2.11327
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.10014
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.04836
PRPF39 pre-mRNA processing factor 39 2.0245
CALML4 calmodulin-like 4 2.02066
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.01185
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.00951

decreased expression

Symbol Name Standardized Value
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.11691
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.36888
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.32743
YME1L1 YME1-like 1 ATPase -3.68077
CHMP4B charged multivesicular body protein 4B -3.11352
LUC7L LUC7-like (S. cerevisiae) -2.8991
SMC1A structural maintenance of chromosomes 1A -2.80258
FBXO21 F-box protein 21 -2.7275
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.70167
THAP11 THAP domain containing 11 -2.56254
NTHL1 nth endonuclease III-like 1 (E. coli) -2.32278
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.30386
RHOT2 ras homolog family member T2 -2.28374
TRIB3 tribbles pseudokinase 3 -2.24043
TSC2 tuberous sclerosis 2 -2.20256
KDM5C lysine (K)-specific demethylase 5C -2.11061
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.07456
TWIST1 twist family bHLH transcription factor 1 -2.06222
CANT1 calcium activated nucleotidase 1 -2.03584
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.02991
MRPL30 mitochondrial ribosomal protein L30 -2.02047
NSUN5 NOP2/Sun domain family, member 5 -2.0036