CRCGN016_MCF10A.TP53.M_24H:D21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acronycine 11.18 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

286 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:D21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 9.4316
MSRA methionine sulfoxide reductase A 8.0457
OXSR1 oxidative stress responsive 1 5.97577
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.57137
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 5.51775
TICAM1 toll-like receptor adaptor molecule 1 5.48988
SQOR sulfide quinone oxidoreductase 4.75915
CORO1A coronin, actin binding protein, 1A 4.5614
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 4.5254
TP53BP2 tumor protein p53 binding protein 2 4.51395
SYNGAP1 synaptic Ras GTPase activating protein 1 4.50769
SOX4 SRY (sex determining region Y)-box 4 4.43721
MINDY1 MINDY lysine 48 deubiquitinase 1 4.27123
LRP10 low density lipoprotein receptor-related protein 10 4.25102
CHIC2 cysteine-rich hydrophobic domain 2 4.2217
MVP major vault protein 4.10252
WIF1 WNT inhibitory factor 1 4.06487
TNIP1 TNFAIP3 interacting protein 1 4.0006
HSPB1 heat shock 27kDa protein 1 3.66403
CLDN7 claudin 7 3.65349
GLRX glutaredoxin (thioltransferase) 3.62553
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.58814
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.58337
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.57094
CDPF1 cysteine-rich, DPF motif domain containing 1 3.48601
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.47193
DUSP4 dual specificity phosphatase 4 3.46039
STAP2 signal transducing adaptor family member 2 3.4406
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.43147
PRSS8 protease, serine, 8 3.34145
CLDN4 claudin 4 3.28184
LSR lipolysis stimulated lipoprotein receptor 3.26917
EPHA2 EPH receptor A2 3.2366
IL1A interleukin 1, alpha 3.20537
C2CD2 C2 calcium-dependent domain containing 2 3.12248
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 3.10401
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.08514
HMOX1 heme oxygenase 1 3.08441
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.08047
CAPN1 calpain 1, (mu/I) large subunit 3.03519
VGLL4 vestigial-like family member 4 3.02361
IL4R interleukin 4 receptor 2.99173
LYRM1 LYR motif containing 1 2.89611
IL1B interleukin 1, beta 2.88522
CCNG2 cyclin G2 2.83981
HBA1 hemoglobin, alpha 1 2.829
CRCT1 cysteine-rich C-terminal 1 2.77619
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.74866
G0S2 G0/G1 switch 2 2.7324
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.69803
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.66818
ACTN4 actinin, alpha 4 2.65001
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.64047
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.63209
ACBD3 acyl-CoA binding domain containing 3 2.57575
TSG101 tumor susceptibility 101 2.55793
NIT1 nitrilase 1 2.51052
ERBB3 erb-b2 receptor tyrosine kinase 3 2.47936
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.47575
TMEM265 transmembrane protein 265 2.47464
MAPK3 mitogen-activated protein kinase 3 2.47207
TCEA2 transcription elongation factor A (SII), 2 2.44621
F3 coagulation factor III (thromboplastin, tissue factor) 2.41902
CCND3 cyclin D3 2.40589
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.38318
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.36845
AMOTL2 angiomotin like 2 2.33357
TMEM40 transmembrane protein 40 2.3234
MFGE8 milk fat globule-EGF factor 8 protein 2.32184
BCL10 B-cell CLL/lymphoma 10 2.31889
TMEM132A transmembrane protein 132A 2.31746
BHLHE40 basic helix-loop-helix family, member e40 2.315
PRSS22 protease, serine, 22 2.30935
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.29772
CLIC4 chloride intracellular channel 4 2.27254
USP6NL USP6 N-terminal like 2.26228
CSNK1E casein kinase 1, epsilon 2.25585
MELK maternal embryonic leucine zipper kinase 2.25033
LCN2 lipocalin 2 2.22839
RAB25 RAB25, member RAS oncogene family 2.22777
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.21914
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.2153
KRT16 keratin 16, type I 2.21287
MARCHF5 membrane associated ring-CH-type finger 5 2.20719
ZC3H12A zinc finger CCCH-type containing 12A 2.19307
MUC1 mucin 1, cell surface associated 2.19287
MYL12B myosin, light chain 12B, regulatory 2.18647
FOSL1 FOS-like antigen 1 2.18595
OCLN occludin 2.17936
BAG3 BCL2-associated athanogene 3 2.16538
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.14071
DDIT4 DNA-damage-inducible transcript 4 2.13798
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.12777
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.11525
FBRS fibrosin 2.1138
ARMCX3 armadillo repeat containing, X-linked 3 2.11338
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 2.11232
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.10618
TSPAN1 tetraspanin 1 2.10083
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.09373
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 2.09194
ITPKC inositol-trisphosphate 3-kinase C 2.09067
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.08684
GTPBP2 GTP binding protein 2 2.08078
TM9SF2 transmembrane 9 superfamily member 2 2.07908
GRAMD2B GRAM domain containing 2B 2.0664
PLAUR plasminogen activator, urokinase receptor 2.06422
EHD1 EH-domain containing 1 2.059
DCTN6 dynactin 6 2.05889
PLK3 polo-like kinase 3 2.05016
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.0499
HLA-A major histocompatibility complex, class I, A 2.04424
STX4 syntaxin 4 2.04199
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.03189
STXBP2 syntaxin binding protein 2 2.02897
BAX BCL2-associated X protein 2.02833
PPP4C protein phosphatase 4, catalytic subunit 2.02145
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.01808
CANT1 calcium activated nucleotidase 1 2.00996

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.67897
HSPA1A heat shock 70kDa protein 1A -5.53446
ANKRD10 ankyrin repeat domain 10 -5.50701
CCNB2 cyclin B2 -4.57022
HOXA5 homeobox A5 -4.51127
MSMO1 methylsterol monooxygenase 1 -4.43556
CYCS cytochrome c, somatic -3.94258
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.93035
SH3D19 SH3 domain containing 19 -3.80533
MCM3 minichromosome maintenance complex component 3 -3.80308
CDC45 cell division cycle 45 -3.7093
INSIG1 insulin induced gene 1 -3.48242
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.44552
HMG20B high mobility group 20B -3.39096
ZSCAN5A zinc finger and SCAN domain containing 5A -3.38214
GRWD1 glutamate-rich WD repeat containing 1 -3.36787
TMEM97 transmembrane protein 97 -3.24953
NCAPD2 non-SMC condensin I complex, subunit D2 -3.24702
PSRC1 proline/serine-rich coiled-coil 1 -3.19978
LBR lamin B receptor -3.18254
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.17845
PARP1 poly (ADP-ribose) polymerase 1 -3.13953
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.1291
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -3.11616
PARPBP PARP1 binding protein -3.0926
TSC22D3 TSC22 domain family, member 3 -3.05502
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.02963
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.01886
SOAT2 sterol O-acyltransferase 2 -3.00635
OIP5 Opa interacting protein 5 -2.99226
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.97153
CDK4 cyclin-dependent kinase 4 -2.95652
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.92541
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.84254
PSIP1 PC4 and SFRS1 interacting protein 1 -2.8175
PMM2 phosphomannomutase 2 -2.77932
OAT ornithine aminotransferase -2.74094
NUP133 nucleoporin 133kDa -2.73176
TIMELESS timeless circadian clock -2.72668
ECH1 enoyl CoA hydratase 1, peroxisomal -2.71768
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.71354
WDR3 WD repeat domain 3 -2.70535
CBR1 carbonyl reductase 1 -2.68295
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.68228
ACLY ATP citrate lyase -2.67788
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.65144
POLR1G RNA polymerase I subunit G -2.63588
USP1 ubiquitin specific peptidase 1 -2.6337
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.61933
NCAPH non-SMC condensin I complex, subunit H -2.60949
BRCA1 breast cancer 1, early onset -2.6015
CD320 CD320 molecule -2.57545
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.56646
KIF20A kinesin family member 20A -2.56029
INTS14 integrator complex subunit 14 -2.5461
CDC6 cell division cycle 6 -2.54495
NAT10 N-acetyltransferase 10 (GCN5-related) -2.52293
MYO19 myosin XIX -2.51845
TXNRD3 thioredoxin reductase 3 -2.51172
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.50965
ZBTB24 zinc finger and BTB domain containing 24 -2.50692
GGCT gamma-glutamylcyclotransferase -2.49183
DKC1 dyskeratosis congenita 1, dyskerin -2.46664
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.46152
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -2.45347
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.45103
KIF18A kinesin family member 18A -2.45044
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.44349
SGK1 serum/glucocorticoid regulated kinase 1 -2.42694
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.41372
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.40723
ACOD1 aconitate decarboxylase 1 -2.40577
EXO1 exonuclease 1 -2.39993
TIPIN TIMELESS interacting protein -2.39918
UNG uracil-DNA glycosylase -2.38839
ZNF263 zinc finger protein 263 -2.38323
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.3815
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -2.37286
DPH2 DPH2 homolog (S. cerevisiae) -2.3668
MCMBP minichromosome maintenance complex binding protein -2.36403
NUP85 nucleoporin 85kDa -2.36172
MCM6 minichromosome maintenance complex component 6 -2.34601
ISOC2 isochorismatase domain containing 2 -2.34111
BLCAP bladder cancer associated protein -2.32554
SQLE squalene epoxidase -2.31546
TRAP1 TNF receptor-associated protein 1 -2.31147
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.29358
KIF14 kinesin family member 14 -2.29124
CBR3 carbonyl reductase 3 -2.28299
WDCP WD repeat and coiled coil containing -2.28003
CENPA centromere protein A -2.27774
CCP110 centriolar coiled coil protein 110kDa -2.26604
NUP93 nucleoporin 93kDa -2.26521
WASF3 WAS protein family, member 3 -2.25478
AUNIP aurora kinase A and ninein interacting protein -2.24526
VAT1 vesicle amine transport 1 -2.23534
ERCC6L excision repair cross-complementation group 6-like -2.23173
TOP2A topoisomerase (DNA) II alpha 170kDa -2.22675
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.22472
NCAPD3 non-SMC condensin II complex, subunit D3 -2.21783
ICE2 interactor of little elongation complex ELL subunit 2 -2.21726
PIMREG PICALM interacting mitotic regulator -2.21224
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.21196
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.20551
SMYD3 SET and MYND domain containing 3 -2.20018
ARHGAP11A Rho GTPase activating protein 11A -2.19131
CDCA4 cell division cycle associated 4 -2.18687
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.18075
ALDOC aldolase C, fructose-bisphosphate -2.17251
PLXND1 plexin D1 -2.16855
TEX10 testis expressed 10 -2.16761
MPHOSPH9 M-phase phosphoprotein 9 -2.16678
NASP nuclear autoantigenic sperm protein (histone-binding) -2.16418
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.16343
CAMKMT calmodulin-lysine N-methyltransferase -2.16059
KIF4A kinesin family member 4A -2.16038
ANXA2 annexin A2 -2.15639
CPZ carboxypeptidase Z -2.15613
PARP2 poly (ADP-ribose) polymerase 2 -2.15229
RPGRIP1L RPGRIP1-like -2.15176
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.15098
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.15006
MRPS2 mitochondrial ribosomal protein S2 -2.14726
MIURF mitochondrial elongation factor 1 upstream open reading frame -2.1421
EXOSC5 exosome component 5 -2.14067
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.13638
MAGEA12 melanoma antigen family A12 -2.1256
SLC38A6 solute carrier family 38, member 6 -2.12242
FEN1 flap structure-specific endonuclease 1 -2.11299
TMX2 thioredoxin-related transmembrane protein 2 -2.10684
ZNF280D zinc finger protein 280D -2.10429
NT5DC2 5'-nucleotidase domain containing 2 -2.10075
COQ3 coenzyme Q3 methyltransferase -2.10051
CHODL chondrolectin -2.09537
CDC7 cell division cycle 7 -2.09493
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.09331
TRAM2 translocation associated membrane protein 2 -2.09166
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.08664
EIF3J eukaryotic translation initiation factor 3, subunit J -2.08544
CCNF cyclin F -2.08376
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.07957
DNA2 DNA replication helicase/nuclease 2 -2.07819
BIRC5 baculoviral IAP repeat containing 5 -2.07778
FOXM1 forkhead box M1 -2.07579
SPC25 SPC25, NDC80 kinetochore complex component -2.06507
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 -2.06287
DUT deoxyuridine triphosphatase -2.05973
EGFL6 EGF-like-domain, multiple 6 -2.05918
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -2.05912
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.05418
MAGEB2 melanoma antigen family B2 -2.05265
PUS1 pseudouridylate synthase 1 -2.05075
RBL1 retinoblastoma-like 1 -2.05067
TTC28 tetratricopeptide repeat domain 28 -2.04853
DHODH dihydroorotate dehydrogenase (quinone) -2.04551
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.04043
OLFML1 olfactomedin-like 1 -2.02603
KIAA0586 KIAA0586 -2.02459
SCARB1 scavenger receptor class B, member 1 -2.02219
TUBGCP5 tubulin, gamma complex associated protein 5 -2.01823
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.01556
TUBGCP4 tubulin, gamma complex associated protein 4 -2.01274
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.01139
COL16A1 collagen, type XVI, alpha 1 -2.00864
TCERG1 transcription elongation regulator 1 -2.00288
COMMD9 COMM domain containing 9 -2.00246
POLR1B polymerase (RNA) I polypeptide B, 128kDa -2.00016