CRCGN016_MCF10A.TP53.M_24H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 101.47 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

162 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.53035
ITFG1 integrin alpha FG-GAP repeat containing 1 3.97431
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.56105
SPAG4 sperm associated antigen 4 3.47898
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.28111
CRELD2 cysteine-rich with EGF-like domains 2 3.24516
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.21139
ACP2 acid phosphatase 2, lysosomal 3.13509
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.13461
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.10005
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.05923
ACAA1 acetyl-CoA acyltransferase 1 2.94168
SARS1 seryl-tRNA synthetase 1 2.84399
TRIB3 tribbles pseudokinase 3 2.78795
MMP2 matrix metallopeptidase 2 2.77848
LOC102724560 cystathionine beta-synthase 2.72366
EXT1 exostosin glycosyltransferase 1 2.70665
ATP11B ATPase, class VI, type 11B 2.70504
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.69106
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.6882
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.64398
ASGR2 asialoglycoprotein receptor 2 2.61667
SAA4 serum amyloid A4, constitutive 2.60667
GLRX glutaredoxin (thioltransferase) 2.56763
CERK ceramide kinase 2.53093
PMM2 phosphomannomutase 2 2.51346
BCKDK branched chain ketoacid dehydrogenase kinase 2.46969
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.46738
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.42426
RTL8A retrotransposon Gag like 8A 2.37748
DPYS dihydropyrimidinase 2.37501
CLEC10A C-type lectin domain family 10, member A 2.36485
PPOX protoporphyrinogen oxidase 2.34627
ORM2 orosomucoid 2 2.32764
HABP2 hyaluronan binding protein 2 2.30372
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.28925
USP3 ubiquitin specific peptidase 3 2.28485
MCTP1 multiple C2 domains, transmembrane 1 2.2766
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 2.26681
INHBB inhibin, beta B 2.25608
NIT1 nitrilase 1 2.25254
GC group-specific component (vitamin D binding protein) 2.25201
INHBE inhibin, beta E 2.24921
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.24105
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.23358
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.23081
APOC3 apolipoprotein C-III 2.22237
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 2.21263
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.21028
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.20681
GCHFR GTP cyclohydrolase I feedback regulator 2.19762
MOGS mannosyl-oligosaccharide glucosidase 2.19397
VNN1 vanin 1 2.1713
MAN2C1 mannosidase, alpha, class 2C, member 1 2.17124
ZNF768 zinc finger protein 768 2.17037
H2BC21 H2B clustered histone 21 2.16895
ANGPTL8 angiopoietin like 8 2.14212
IL15RA interleukin 15 receptor, alpha 2.13425
LMBR1L limb development membrane protein 1-like 2.13386
APOB apolipoprotein B 2.13269
PHGDH phosphoglycerate dehydrogenase 2.12979
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 2.1241
APCS amyloid P component, serum 2.12305
TMEM177 transmembrane protein 177 2.12202
INSIG2 insulin induced gene 2 2.12094
DEPP1 DEPP autophagy regulator 1 2.10933
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.09939
CFHR2 complement factor H-related 2 2.09431
CDCP1 CUB domain containing protein 1 2.08321
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.07585
THAP4 THAP domain containing 4 2.06616
STX4 syntaxin 4 2.04112
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.03834
ZFTA zinc finger translocation associated 2.03652
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.03075
AMBP alpha-1-microglobulin/bikunin precursor 2.02136
CARS1 cysteinyl-tRNA synthetase 1 2.01665
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.01538
H2BC9 H2B clustered histone 9 2.01529
MBL2 mannose-binding lectin (protein C) 2, soluble 2.01307
CELA3A chymotrypsin-like elastase family, member 3A 2.00862
WDR19 WD repeat domain 19 2.00797
RTN1 reticulon 1 2.00626
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.00565
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.00152
STARD3 StAR-related lipid transfer (START) domain containing 3 2.00038

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.73098
PCNA proliferating cell nuclear antigen -5.62406
CCNB1 cyclin B1 -4.96043
CYCS cytochrome c, somatic -4.8181
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.4331
COX5A cytochrome c oxidase subunit Va -3.27163
ADRB2 adrenoceptor beta 2, surface -3.22954
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.21264
STMN1 stathmin 1 -3.20256
CDC20 cell division cycle 20 -3.18679
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.12737
YME1L1 YME1-like 1 ATPase -2.92572
FASTKD5 FAST kinase domains 5 -2.84225
ITGB8 integrin, beta 8 -2.70535
RFC2 replication factor C (activator 1) 2, 40kDa -2.69078
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.65896
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.58858
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.56272
UPK3B uroplakin 3B -2.55396
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.50616
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.4585
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.44875
IQGAP1 IQ motif containing GTPase activating protein 1 -2.42886
LDHD lactate dehydrogenase D -2.38471
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.35408
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.33737
SERF1A small EDRK-rich factor 1A (telomeric) -2.32573
EIF4A3 eukaryotic translation initiation factor 4A3 -2.3248
HSPA1A heat shock 70kDa protein 1A -2.31988
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.28892
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.2764
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.27212
PGAM2 phosphoglycerate mutase 2 (muscle) -2.25483
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.2475
RBBP4 retinoblastoma binding protein 4 -2.23955
MCM10 minichromosome maintenance complex component 10 -2.23243
EBNA1BP2 EBNA1 binding protein 2 -2.229
SELENOF selenoprotein F -2.21791
CDK1 cyclin-dependent kinase 1 -2.21675
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.21186
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.20563
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.20059
DUSP14 dual specificity phosphatase 14 -2.19066
OSTF1 osteoclast stimulating factor 1 -2.18929
RAB11FIP1 RAB11 family interacting protein 1 (class I) -2.18615
HEBP2 heme binding protein 2 -2.16861
BAG3 BCL2-associated athanogene 3 -2.16855
TUBB6 tubulin, beta 6 class V -2.16312
CAVIN2 caveolae associated protein 2 -2.15716
IGFBP7 insulin-like growth factor binding protein 7 -2.15248
CCNA2 cyclin A2 -2.14197
EIF3I eukaryotic translation initiation factor 3, subunit I -2.14021
ELAVL1 ELAV like RNA binding protein 1 -2.13548
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.13243
MYL12B myosin, light chain 12B, regulatory -2.13156
ECD ecdysoneless homolog (Drosophila) -2.11498
TIPIN TIMELESS interacting protein -2.10398
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.0979
AQP4 aquaporin 4 -2.0867
VRK1 vaccinia related kinase 1 -2.08463
OXSR1 oxidative stress responsive 1 -2.08213
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -2.07831
TENT5A terminal nucleotidyltransferase 5A -2.07631
COBL cordon-bleu WH2 repeat protein -2.06308
DYNLL1 dynein, light chain, LC8-type 1 -2.06046
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.0597
OCLN occludin -2.05802
TJP1 tight junction protein 1 -2.05604
MSN moesin -2.05386
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.03778
CLDN18 claudin 18 -2.03454
CKS2 CDC28 protein kinase regulatory subunit 2 -2.02716
OXA1L oxidase (cytochrome c) assembly 1-like -2.02571
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.01639
MX2 MX dynamin-like GTPase 2 -2.00275
GMDS GDP-mannose 4,6-dehydratase -2.00053