CRCGN016_MCF10A.TP53.M_24H:E06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diphenyl-p-phenylenediamine 11.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:E06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 5.11978
ADGRE5 adhesion G protein-coupled receptor E5 5.03392
CXCL2 chemokine (C-X-C motif) ligand 2 4.69833
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.64711
AGR2 anterior gradient 2 4.61159
ABHD4 abhydrolase domain containing 4 4.45888
SNAP25 synaptosomal-associated protein, 25kDa 4.36283
RBM15B RNA binding motif protein 15B 3.37586
MAP7 microtubule-associated protein 7 3.29129
KDM5D lysine (K)-specific demethylase 5D 2.89321
RBKS ribokinase 2.85683
CNRIP1 cannabinoid receptor interacting protein 1 2.55518
UBB ubiquitin B 2.53298
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.48049
TLCD3A TLC domain containing 3A 2.44758
TOMM34 translocase of outer mitochondrial membrane 34 2.37465
COMP cartilage oligomeric matrix protein 2.34866
RWDD2B RWD domain containing 2B 2.34474
AKR1C3 aldo-keto reductase family 1, member C3 2.31491
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.30609
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.28535
PARP3 poly (ADP-ribose) polymerase family, member 3 2.22223
QDPR quinoid dihydropteridine reductase 2.05507
CXCL3 chemokine (C-X-C motif) ligand 3 2.05016

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -6.23626
TM9SF3 transmembrane 9 superfamily member 3 -5.09589
DNM1L dynamin 1-like -4.94477
FASTKD5 FAST kinase domains 5 -4.56176
TNIP1 TNFAIP3 interacting protein 1 -4.5592
NUP85 nucleoporin 85kDa -4.45844
UFM1 ubiquitin-fold modifier 1 -4.11716
MSN moesin -4.04372
S100A8 S100 calcium binding protein A8 -3.78376
SGK1 serum/glucocorticoid regulated kinase 1 -3.61904
CTNND1 catenin (cadherin-associated protein), delta 1 -3.5158
MT1X metallothionein 1X -3.34411
C2CD5 C2 calcium-dependent domain containing 5 -3.32942
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.11814
MT2A metallothionein 2A -2.99518
SINHCAF SIN3-HDAC complex associated factor -2.79247
PTK2 protein tyrosine kinase 2 -2.67881
FKBP1C FK506 binding protein 1C -2.66499
VAT1 vesicle amine transport 1 -2.62889
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.59082
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.5514
RESF1 retroelement silencing factor 1 -2.52497
TRAPPC6A trafficking protein particle complex 6A -2.37744
SMC1A structural maintenance of chromosomes 1A -2.25333
CDH5 cadherin 5, type 2 (vascular endothelium) -2.2532
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.24707
CTLA4 cytotoxic T-lymphocyte-associated protein 4 -2.23374
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.23127
WDR45B WD repeat domain 45B -2.22941
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.22284
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.21142
DEPP1 DEPP autophagy regulator 1 -2.15281
UBE2O ubiquitin-conjugating enzyme E2O -2.15111
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.14801
CTSB cathepsin B -2.13885
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.12904
MDM4 MDM4, p53 regulator -2.12002
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.11487
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.10796
CYTH2 cytohesin 2 -2.03578
R3HCC1L R3H domain and coiled-coil containing 1-like -2.02999
PTPRE protein tyrosine phosphatase, receptor type, E -2.00946
KRT15 keratin 15, type I -2.00822