CRCGN016_MCF10A.TP53.M_24H:E14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description g-butyrolactone 32.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

245 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:E14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RAB11FIP2 RAB11 family interacting protein 2 (class I) 5.98598
E2F2 E2F transcription factor 2 5.35794
CXCR4 chemokine (C-X-C motif) receptor 4 4.44177
EMX2 empty spiracles homeobox 2 3.90131
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.85849
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.71909
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.16959
KDM5D lysine (K)-specific demethylase 5D 3.12455
WIF1 WNT inhibitory factor 1 3.00385
MSRA methionine sulfoxide reductase A 2.98811
SKA1 spindle and kinetochore associated complex subunit 1 2.98667
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.98314
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.8813
CAMKMT calmodulin-lysine N-methyltransferase 2.81148
CST4 cystatin S 2.80521
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.79686
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.79026
METRN meteorin, glial cell differentiation regulator 2.78702
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.75287
EP400 E1A binding protein p400 2.74623
COMP cartilage oligomeric matrix protein 2.72721
USP9Y ubiquitin specific peptidase 9, Y-linked 2.71394
MNS1 meiosis-specific nuclear structural 1 2.71128
MAN2B2 mannosidase, alpha, class 2B, member 2 2.7024
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.68019
NLGN4Y neuroligin 4, Y-linked 2.66546
ATXN7L1 ataxin 7-like 1 2.64625
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.64239
LOC124908558 X antigen family member 1-like 2.63648
ADRA2C adrenoceptor alpha 2C 2.63031
SIPA1L1 signal-induced proliferation-associated 1 like 1 2.62089
BBS7 Bardet-Biedl syndrome 7 2.61551
MCPH1 microcephalin 1 2.60693
FGGY FGGY carbohydrate kinase domain containing 2.57211
PHF14 PHD finger protein 14 2.54149
CPAP centrosome assembly and centriole elongation protein 2.54147
ABHD14A abhydrolase domain containing 14A 2.52647
ZNF266 zinc finger protein 266 2.52372
ARHGAP11A Rho GTPase activating protein 11A 2.5164
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 2.49718
MPHOSPH9 M-phase phosphoprotein 9 2.4898
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.48502
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.48331
GALK1 galactokinase 1 2.4723
SGPP1 sphingosine-1-phosphate phosphatase 1 2.47131
GTF2A1 general transcription factor IIA, 1, 19/37kDa 2.47107
PLSCR3 phospholipid scramblase 3 2.47082
DZIP1 DAZ interacting zinc finger protein 1 2.46903
TTC28 tetratricopeptide repeat domain 28 2.45555
MUC7 mucin 7, secreted 2.44688
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.43665
WDR4 WD repeat domain 4 2.42499
MTA2 metastasis associated 1 family, member 2 2.42017
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.41956
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.41896
GJA3 gap junction protein, alpha 3, 46kDa 2.41785
SPC25 SPC25, NDC80 kinetochore complex component 2.41762
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.41129
ATF6B activating transcription factor 6 beta 2.40858
ZMAT5 zinc finger, matrin-type 5 2.40837
CCDC22 coiled-coil domain containing 22 2.38375
NMUR1 neuromedin U receptor 1 2.37231
LCN1 lipocalin 1 2.36614
ODF2 outer dense fiber of sperm tails 2 2.36507
ZNF592 zinc finger protein 592 2.36192
OCEL1 occludin/ELL domain containing 1 2.36073
MATN4 matrilin 4 2.35084
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.34489
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.3352
FGF8 fibroblast growth factor 8 (androgen-induced) 2.32976
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.32396
DDHD2 DDHD domain containing 2 2.32171
GLP2R glucagon-like peptide 2 receptor 2.31364
SSX5 synovial sarcoma, X breakpoint 5 2.30511
SPA17 sperm autoantigenic protein 17 2.30375
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.28183
PDE7B phosphodiesterase 7B 2.27699
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.27443
TCP11L1 t-complex 11, testis-specific-like 1 2.27376
MXD1 MAX dimerization protein 1 2.2691
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.26319
MTNR1B melatonin receptor 1B 2.26067
MIS18A MIS18 kinetochore protein A 2.25689
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.25688
SPATA31A3 SPATA31 subfamily A, member 3 2.25509
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.2504
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.25037
KRT33A keratin 33A, type I 2.24465
STATH statherin 2.24225
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.23796
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.23299
TTC26 tetratricopeptide repeat domain 26 2.22819
TBC1D19 TBC1 domain family, member 19 2.22693
NPY4R2 neuropeptide Y receptor Y4-2 2.22379
IL19 interleukin 19 2.22242
RNFT2 ring finger protein, transmembrane 2 2.2222
PADI4 peptidyl arginine deiminase, type IV 2.2166
CDHR5 cadherin-related family member 5 2.20692
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.20566
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 2.20478
POU3F3 POU class 3 homeobox 3 2.19637
NADSYN1 NAD synthetase 1 2.19253
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.19212
PRDM4 PR domain containing 4 2.18382
RPGR retinitis pigmentosa GTPase regulator 2.18025
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.17684
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.17003
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.16763
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.16596
HOXA11 homeobox A11 2.16574
KRT3 keratin 3, type II 2.16324
IL13 interleukin 13 2.16197
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.15969
PRAMEF12 PRAME family member 12 2.15641
AFF3 AF4/FMR2 family, member 3 2.15609
MYO19 myosin XIX 2.15499
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.14897
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 2.14784
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 2.14753
GFI1 growth factor independent 1 transcription repressor 2.14677
LIN7A lin-7 homolog A (C. elegans) 2.1461
TWSG1 twisted gastrulation BMP signaling modulator 1 2.14004
ARHGAP24 Rho GTPase activating protein 24 2.13619
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.13234
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 2.12879
CBARP CACN subunit beta associated regulatory protein 2.12504
ACBD4 acyl-CoA binding domain containing 4 2.12255
CER1 cerberus 1, DAN family BMP antagonist 2.12159
RBL1 retinoblastoma-like 1 2.12097
SYTL3 synaptotagmin-like 3 2.11875
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 2.11613
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.11418
NCOA6 nuclear receptor coactivator 6 2.11359
TREH trehalase (brush-border membrane glycoprotein) 2.11085
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.10956
REG1A regenerating islet-derived 1 alpha 2.10698
GPR68 G protein-coupled receptor 68 2.10596
ZNF428 zinc finger protein 428 2.10317
CST2 cystatin SA 2.10261
CLCN2 chloride channel, voltage-sensitive 2 2.10079
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.10056
PRH1 proline-rich protein HaeIII subfamily 1 2.10048
LIFR leukemia inhibitory factor receptor alpha 2.09986
HIC1 hypermethylated in cancer 1 2.09843
PRDM8 PR domain containing 8 2.0968
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.09572
GMIP GEM interacting protein 2.09157
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.08771
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.08243
GSTM5 glutathione S-transferase mu 5 2.08125
MYH15 myosin, heavy chain 15 2.0807
CIRBP cold inducible RNA binding protein 2.08036
QSER1 glutamine and serine rich 1 2.07806
SAMD14 sterile alpha motif domain containing 14 2.07209
CCL23 chemokine (C-C motif) ligand 23 2.06767
PTPRJ protein tyrosine phosphatase, receptor type, J 2.06426
RFX1 regulatory factor X, 1 (influences HLA class II expression) 2.05985
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2.0594
BLK BLK proto-oncogene, Src family tyrosine kinase 2.05932
IL12RB2 interleukin 12 receptor, beta 2 2.05717
SNW1 SNW domain containing 1 2.05633
SATB1 SATB homeobox 1 2.05454
POU2F2 POU class 2 homeobox 2 2.05371
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.05229
WRAP53 WD repeat containing, antisense to TP53 2.05045
CCDC134 coiled-coil domain containing 134 2.05036
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.04947
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.04915
TOMM34 translocase of outer mitochondrial membrane 34 2.04869
DGKG diacylglycerol kinase, gamma 90kDa 2.04771
MMP27 matrix metallopeptidase 27 2.04608
VSTM4 V-set and transmembrane domain containing 4 2.04607
EBF2 early B-cell factor 2 2.046
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.04534
TLR6 toll-like receptor 6 2.0438
DUS2 dihydrouridine synthase 2 2.0414
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.03834
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.03826
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.03508
ZNF556 zinc finger protein 556 2.03286
HLA-DOA major histocompatibility complex, class II, DO alpha 2.03198
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.03152
KRT36 keratin 36, type I 2.02718
PARPBP PARP1 binding protein 2.02673
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 2.02521
BTN1A1 butyrophilin, subfamily 1, member A1 2.02214
CSAG2 CSAG family, member 2 2.02008
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.01994
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.01473
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.01329
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.01043
RSRC2 arginine/serine-rich coiled-coil 2 2.00993
EDN2 endothelin 2 2.00922
ASIC4 acid sensing (proton gated) ion channel family member 4 2.00873
RBMS3 RNA binding motif, single stranded interacting protein 3 2.00654
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.00423

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.66282
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.94441
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.63984
BAG3 BCL2-associated athanogene 3 -4.50307
SGK1 serum/glucocorticoid regulated kinase 1 -3.77834
TOPBP1 topoisomerase (DNA) II binding protein 1 -3.43896
GHITM growth hormone inducible transmembrane protein -3.27949
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -3.12217
IPO13 importin 13 -2.9338
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.93107
SORBS3 sorbin and SH3 domain containing 3 -2.75729
S100A8 S100 calcium binding protein A8 -2.70954
UBA2 ubiquitin-like modifier activating enzyme 2 -2.59542
GDF15 growth differentiation factor 15 -2.57548
UNC50 unc-50 homolog (C. elegans) -2.51119
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.46415
ABHD17A abhydrolase domain containing 17A -2.46287
TUBA4A tubulin, alpha 4a -2.43539
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.41389
PCID2 PCI domain containing 2 -2.38518
KDM3A lysine (K)-specific demethylase 3A -2.38135
C1QBP complement component 1, q subcomponent binding protein -2.36512
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.3501
DSG2 desmoglein 2 -2.34782
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.34661
AVPI1 arginine vasopressin-induced 1 -2.33892
ITPKB inositol-trisphosphate 3-kinase B -2.29234
GLRX2 glutaredoxin 2 -2.29216
BFAR bifunctional apoptosis regulator -2.26552
NELFCD negative elongation factor complex member C/D -2.25979
MAGT1 magnesium transporter 1 -2.24545
WASHC5 WASH complex subunit 5 -2.23743
FXYD3 FXYD domain containing ion transport regulator 3 -2.2044
PCNA proliferating cell nuclear antigen -2.20192
TRIB3 tribbles pseudokinase 3 -2.18758
ISOC1 isochorismatase domain containing 1 -2.16572
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.14428
ZDHHC6 zinc finger, DHHC-type containing 6 -2.10145
H2AC25 H2A clustered histone 25 -2.09279
PRSS8 protease, serine, 8 -2.09131
TEX10 testis expressed 10 -2.08796
MAIP1 matrix AAA peptidase interacting protein 1 -2.07407
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.04854
CD53 CD53 molecule -2.0469
MPHOSPH8 M-phase phosphoprotein 8 -2.04599
PHLDA2 pleckstrin homology-like domain, family A, member 2 -2.04175
CDC34 cell division cycle 34 -2.01577
PILRB paired immunoglobin-like type 2 receptor beta -2.00776
RNF130 ring finger protein 130 -2.00238