CRCGN016_MCF10A.TP53.M_24H:E16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl acetate 104.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:E16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBP TATA box binding protein 4.2965
GPER1 G protein-coupled estrogen receptor 1 4.19315
GRB10 growth factor receptor-bound protein 10 4.08038
STAP2 signal transducing adaptor family member 2 3.60348
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.5557
ANO10 anoctamin 10 3.26451
PRKX protein kinase, X-linked 3.15821
IGHMBP2 immunoglobulin mu binding protein 2 3.07446
TIAM1 T-cell lymphoma invasion and metastasis 1 2.89738
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.77418
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.7735
HLA-DRA major histocompatibility complex, class II, DR alpha 2.77154
KDM5D lysine (K)-specific demethylase 5D 2.26557
MOSPD3 motile sperm domain containing 3 2.18779
COIL coilin 2.146
ANKRD11 ankyrin repeat domain 11 2.00023

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -5.80481
BASP1 brain abundant, membrane attached signal protein 1 -5.17921
RPIA ribose 5-phosphate isomerase A -5.07573
HEATR1 HEAT repeat containing 1 -4.4483
HAT1 histone acetyltransferase 1 -4.12892
PRPF4 pre-mRNA processing factor 4 -4.02224
BID BH3 interacting domain death agonist -3.7432
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.7071
MSN moesin -3.58921
CCNB1 cyclin B1 -3.31847
VDAC1 voltage-dependent anion channel 1 -3.18415
KDM3A lysine (K)-specific demethylase 3A -2.88681
SGK1 serum/glucocorticoid regulated kinase 1 -2.76306
RAI14 retinoic acid induced 14 -2.73633
COTL1 coactosin-like F-actin binding protein 1 -2.40669
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.30616
NEFH neurofilament, heavy polypeptide -2.29395
STEAP3 STEAP family member 3, metalloreductase -2.29051
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.17928
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.177
STEAP1 six transmembrane epithelial antigen of the prostate 1 -2.08548
CHD1 chromodomain helicase DNA binding protein 1 -2.06259
ERBIN erbb2 interacting protein -2.03991
ALAD aminolevulinate dehydratase -2.0299
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.01673
RCN1 reticulocalbin 1, EF-hand calcium binding domain -2.00094