CRCGN016_MCF10A.TP53.M_24H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[(4-oxo-1,2,3-benzotriazin-3(4h)-yl)methyl] dithiophosphate 101.85 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

53 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.9791
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.9811
ZNF586 zinc finger protein 586 2.7562
TCTN1 tectonic family member 1 2.64555
MAP7 microtubule-associated protein 7 2.48278
DVL1 dishevelled segment polarity protein 1 2.44135
DEGS1 delta(4)-desaturase, sphingolipid 1 2.31722
MINDY1 MINDY lysine 48 deubiquitinase 1 2.3011
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.2294
KCTD5 potassium channel tetramerization domain containing 5 2.1912
NELFA negative elongation factor complex member A 2.09573
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.07565
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.0691
GLRX glutaredoxin (thioltransferase) 2.06157
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.03005
ATP5ME ATP synthase membrane subunit e 2.02605
GTF3A general transcription factor IIIA 2.02198
MAP2K5 mitogen-activated protein kinase kinase 5 2.00258

decreased expression

Symbol Name Standardized Value
PGAM4 phosphoglycerate mutase family member 4 -5.493
TXNDC9 thioredoxin domain containing 9 -5.18385
ADI1 acireductone dioxygenase 1 -5.00445
HOXA5 homeobox A5 -4.95205
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.25875
ZFP36 ZFP36 ring finger protein -4.0243
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.7905
SGK1 serum/glucocorticoid regulated kinase 1 -3.454
TCEA2 transcription elongation factor A (SII), 2 -3.08065
GADD45B growth arrest and DNA-damage-inducible, beta -2.93173
CLIC4 chloride intracellular channel 4 -2.92175
STMN1 stathmin 1 -2.90865
HSPA1A heat shock 70kDa protein 1A -2.83145
MT2A metallothionein 2A -2.7472
PRR15L proline rich 15-like -2.7314
FAM13B family with sequence similarity 13, member B -2.55035
NFIL3 nuclear factor, interleukin 3 regulated -2.45765
LMAN2L lectin, mannose-binding 2-like -2.45405
TMEM14A transmembrane protein 14A -2.4098
NRIP1 nuclear receptor interacting protein 1 -2.38485
LIFR leukemia inhibitory factor receptor alpha -2.3684
LIPT1 lipoyltransferase 1 -2.32065
REV1 REV1, polymerase (DNA directed) -2.28195
CCL3L3 chemokine (C-C motif) ligand 3-like 3 -2.26625
PDCD10 programmed cell death 10 -2.24005
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.23787
HOXA10-HOXA9 HOXA10-HOXA9 readthrough -2.22743
MT1X metallothionein 1X -2.21622
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.1956
CDK1 cyclin-dependent kinase 1 -2.16357
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.1167
CCDC47 coiled-coil domain containing 47 -2.1084
ANKRD10 ankyrin repeat domain 10 -2.0971
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.07835
IFNG interferon, gamma -2.05955