CRCGN016_MCF10A.TP53.M_24H:F06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triclosan 11.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:F06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC85B coiled-coil domain containing 85B 3.22516
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.00737
ACAA1 acetyl-CoA acyltransferase 1 2.64284
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.58558
MMP1 matrix metallopeptidase 1 2.50734
ACBD3 acyl-CoA binding domain containing 3 2.24676
TOMM34 translocase of outer mitochondrial membrane 34 2.24552
PNKP polynucleotide kinase 3'-phosphatase 2.2317
TSPAN4 tetraspanin 4 2.04113

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -5.12195
WASHC4 WASH complex subunit 4 -4.02751
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -4.00976
HOXA5 homeobox A5 -3.954
HSPA1A heat shock 70kDa protein 1A -3.78064
MRPS2 mitochondrial ribosomal protein S2 -3.74808
HAT1 histone acetyltransferase 1 -3.41871
PAEP progestagen-associated endometrial protein -2.9942
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.75084
BASP1 brain abundant, membrane attached signal protein 1 -2.67187
TRAPPC6A trafficking protein particle complex 6A -2.53916
INSIG1 insulin induced gene 1 -2.5145
PPY pancreatic polypeptide -2.42599
PMM2 phosphomannomutase 2 -2.39328
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.38838
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.32818
TLK2 tousled-like kinase 2 -2.32256
PIH1D1 PIH1 domain containing 1 -2.27795
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.23636
VAT1 vesicle amine transport 1 -2.13461
TSC1 tuberous sclerosis 1 -2.1142
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.09127
PIERCE1 piercer of microtubule wall 1 -2.04928
HOXA4 homeobox A4 -2.03258
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.0225
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.01219
RASAL2 RAS protein activator like 2 -2.00097