CRCGN016_MCF10A.TP53.M_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description eugenol 100.46 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

116 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 5.56097
E2F2 E2F transcription factor 2 4.59348
RPL39L ribosomal protein L39-like 4.45478
INTS3 integrator complex subunit 3 4.36278
ABHD4 abhydrolase domain containing 4 4.24285
SSBP2 single-stranded DNA binding protein 2 3.85216
KDM5D lysine (K)-specific demethylase 5D 2.8722
MELK maternal embryonic leucine zipper kinase 2.73835
RAB21 RAB21, member RAS oncogene family 2.67217
CETN3 centrin, EF-hand protein, 3 2.62589
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.59989
ODF2 outer dense fiber of sperm tails 2 2.59146
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.5628
BACE2 beta-site APP-cleaving enzyme 2 2.48665
PIBF1 progesterone immunomodulatory binding factor 1 2.43234
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.40019
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.38493
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.38279
RSAD1 radical S-adenosyl methionine domain containing 1 2.37841
MCPH1 microcephalin 1 2.35146
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.32535
TTC27 tetratricopeptide repeat domain 27 2.30545
WDR70 WD repeat domain 70 2.30393
DENND2D DENN/MADD domain containing 2D 2.292
AGBL5 ATP/GTP binding protein-like 5 2.28758
NFE2 nuclear factor, erythroid 2 2.27396
TOMM34 translocase of outer mitochondrial membrane 34 2.27034
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.26551
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.23057
TBCE tubulin folding cofactor E 2.2126
MCRS1 microspherule protein 1 2.20195
ZNF428 zinc finger protein 428 2.16032
SATB1 SATB homeobox 1 2.14976
EXOC2 exocyst complex component 2 2.13178
RNF14 ring finger protein 14 2.12545
TADA2A transcriptional adaptor 2A 2.11562
PDPN podoplanin 2.11304
SEH1L SEH1-like (S. cerevisiae) 2.10704
ARB2A ARB2 cotranscriptional regulator A 2.10291
ALX1 ALX homeobox 1 2.09627
GOLGA3 golgin A3 2.08561
FER fer (fps/fes related) tyrosine kinase 2.08441
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.07044
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.05955
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.05829
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.04967
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.03971
ZNF165 zinc finger protein 165 2.03594
PURA purine-rich element binding protein A 2.0188
ADA adenosine deaminase 2.01289
LPIN2 lipin 2 2.00613

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.10022
PARP2 poly (ADP-ribose) polymerase 2 -5.06579
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.90673
YME1L1 YME1-like 1 ATPase -4.57303
MSN moesin -4.27502
PGAM4 phosphoglycerate mutase family member 4 -4.04878
C2CD5 C2 calcium-dependent domain containing 5 -3.98047
TSPAN4 tetraspanin 4 -3.96048
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -3.9043
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.82552
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -3.77804
ENOPH1 enolase-phosphatase 1 -3.65292
SLC35F2 solute carrier family 35, member F2 -3.65078
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -3.34785
IER3 immediate early response 3 -3.27785
METTL17 methyltransferase like 17 -3.2425
FGR FGR proto-oncogene, Src family tyrosine kinase -3.06537
SMC1A structural maintenance of chromosomes 1A -2.90984
MSMO1 methylsterol monooxygenase 1 -2.88736
TKT transketolase -2.85564
ANXA2 annexin A2 -2.8421
CIDEB cell death-inducing DFFA-like effector b -2.79292
DYSF dysferlin -2.72154
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.71048
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.63061
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.62146
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.61785
THAP11 THAP domain containing 11 -2.61566
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.55418
FLCN folliculin -2.39302
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.38415
SGK1 serum/glucocorticoid regulated kinase 1 -2.37686
NUP54 nucleoporin 54kDa -2.32123
ASPA aspartoacylase -2.31728
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -2.24608
TM9SF1 transmembrane 9 superfamily member 1 -2.24118
SYTL2 synaptotagmin-like 2 -2.23883
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.23285
H2AZ1 H2A.Z variant histone 1 -2.22079
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.21331
PUDP pseudouridine 5'-phosphatase -2.20653
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.20098
THBS1 thrombospondin 1 -2.19858
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.14363
USP3 ubiquitin specific peptidase 3 -2.12891
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.12395
REEP5 receptor accessory protein 5 -2.12381
COTL1 coactosin-like F-actin binding protein 1 -2.1147
CRY2 cryptochrome circadian clock 2 -2.10674
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.0924
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.08623
MAG myelin associated glycoprotein -2.07245
EPHA2 EPH receptor A2 -2.06774
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -2.06255
RNASE4 ribonuclease, RNase A family, 4 -2.0533
DCX doublecortin -2.04827
NKG7 natural killer cell granule protein 7 -2.04691
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.04261
KLHL2 kelch-like family member 2 -2.03582
CST7 cystatin F (leukocystatin) -2.03468
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -2.03408
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.02397
DNM3 dynamin 3 -2.0131
CILK1 ciliogenesis associated kinase 1 -2.01284
TUBA4A tubulin, alpha 4a -2.00144