CRCGN016_MCF10A.TP53.M_24H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K88965984 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 4.97203
KCTD5 potassium channel tetramerization domain containing 5 4.89414
GATD3 glutamine amidotransferase class 1 domain containing 3 4.22412
BMP4 bone morphogenetic protein 4 4.18419
PFKL phosphofructokinase, liver 3.568
GSTZ1 glutathione S-transferase zeta 1 3.36066
MAST2 microtubule associated serine/threonine kinase 2 3.3428
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 3.23575
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 3.0712
ZNF134 zinc finger protein 134 2.9542
LAGE3 L antigen family, member 3 2.898
ACLY ATP citrate lyase 2.84811
PECR peroxisomal trans-2-enoyl-CoA reductase 2.82561
ZNF211 zinc finger protein 211 2.66179
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.56278
DNM2 dynamin 2 2.5574
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.54265
IDE insulin-degrading enzyme 2.50593
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.39943
ZNF587 zinc finger protein 587 2.3826
DGAT1 diacylglycerol O-acyltransferase 1 2.33314
PCBP4 poly(rC) binding protein 4 2.32903
NUTF2 nuclear transport factor 2 2.32064
FLNA filamin A, alpha 2.31735
UBE2M ubiquitin-conjugating enzyme E2M 2.31682
CNRIP1 cannabinoid receptor interacting protein 1 2.29414
TRIM28 tripartite motif containing 28 2.29378
KAT6B K(lysine) acetyltransferase 6B 2.27554
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.26374
FAM3A family with sequence similarity 3, member A 2.26337
ZNF665 zinc finger protein 665 2.2517
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.23358
ZIM3 zinc finger, imprinted 3 2.21362
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.19289
APOE apolipoprotein E 2.15776
ZNF419 zinc finger protein 419 2.12483
ZNF606 zinc finger protein 606 2.12372
CHMP2A charged multivesicular body protein 2A 2.1155
SFMBT1 Scm-like with four mbt domains 1 2.11056
ZNF551 zinc finger protein 551 2.08039
SH3BP1 SH3-domain binding protein 1 2.04584
FAM111A family with sequence similarity 111, member A 2.0312
TLCD3A TLC domain containing 3A 2.02763
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 2.0109
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.00955

decreased expression

Symbol Name Standardized Value
TIMP1 TIMP metallopeptidase inhibitor 1 -5.3231
TXNDC9 thioredoxin domain containing 9 -5.23764
KIF14 kinesin family member 14 -5.14176
CCNB1 cyclin B1 -5.08764
BASP1 brain abundant, membrane attached signal protein 1 -4.99787
MRPS2 mitochondrial ribosomal protein S2 -4.94887
UNC50 unc-50 homolog (C. elegans) -3.78485
CD58 CD58 molecule -3.73254
PAEP progestagen-associated endometrial protein -3.40062
SEC16A SEC16 homolog A (S. cerevisiae) -3.22881
DSG2 desmoglein 2 -2.71104
CD81 CD81 molecule -2.6286
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.37456
PTPRM protein tyrosine phosphatase, receptor type, M -2.35516
BAG3 BCL2-associated athanogene 3 -2.34381
PIERCE1 piercer of microtubule wall 1 -2.25798
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -2.13949
UBAC1 UBA domain containing 1 -2.11966
CAMSAP1 calmodulin regulated spectrin-associated protein 1 -2.08362
MREG melanoregulin -2.07671
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -2.06303
WDR37 WD repeat domain 37 -2.05698
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.04797