CRCGN016_MCF10A.TP53.M_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methylaniline 11.18 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 4.40668
PRKCH protein kinase C, eta 3.65867
CNPY3 canopy FGF signaling regulator 3 3.60953
AGR2 anterior gradient 2 3.04941
ACLY ATP citrate lyase 2.98658
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.84016
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.76397
ZNF586 zinc finger protein 586 2.63957
GATA3 GATA binding protein 3 2.3284
PROCR protein C receptor, endothelial 2.28302
ASL argininosuccinate lyase 2.25825
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.23717
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.14376
FKBP14 FK506 binding protein 14, 22 kDa 2.14051
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.04112

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -6.90377
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.86182
TUBB6 tubulin, beta 6 class V -3.78628
HMG20B high mobility group 20B -3.51191
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -3.41994
CCNB1 cyclin B1 -3.36769
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -3.36728
CD58 CD58 molecule -3.23782
BASP1 brain abundant, membrane attached signal protein 1 -3.05642
KYAT3 kynurenine aminotransferase 3 -2.99134
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.97689
KIF14 kinesin family member 14 -2.96308
ARID4A AT rich interactive domain 4A (RBP1-like) -2.68948
UFM1 ubiquitin-fold modifier 1 -2.68301
CLIC4 chloride intracellular channel 4 -2.51507
RTRAF RNA transcription, translation and transport factor -2.44481
YME1L1 YME1-like 1 ATPase -2.38375
TOR1A torsin family 1, member A (torsin A) -2.37092
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.2717
PSIP1 PC4 and SFRS1 interacting protein 1 -2.25803
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.22492
RWDD1 RWD domain containing 1 -2.17834
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.12681
RBMX2 RNA binding motif protein, X-linked 2 -2.11483
RNF208 ring finger protein 208 -2.05476
ACYP2 acylphosphatase 2, muscle type -2.05119
HOXC11 homeobox C11 -2.0432
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.03116
TMEM260 transmembrane protein 260 -2.03073
GNAS GNAS complex locus -2.02791
NIPAL2 NIPA-like domain containing 2 -2.01808