CRCGN016_MCF10A.TP53.M_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description theophylline 101.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.78776
SSBP2 single-stranded DNA binding protein 2 3.43452
CADM1 cell adhesion molecule 1 2.9969
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.91048
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.4662
ACAA1 acetyl-CoA acyltransferase 1 2.44716
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 2.32543
C1QA complement component 1, q subcomponent, A chain 2.17721
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.06752
CHN1 chimerin 1 2.05771

decreased expression

Symbol Name Standardized Value
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.12542
DSG2 desmoglein 2 -3.60577
HAT1 histone acetyltransferase 1 -3.50858
HSPA8 heat shock 70kDa protein 8 -3.31586
BASP1 brain abundant, membrane attached signal protein 1 -2.9616
TRAPPC3 trafficking protein particle complex 3 -2.89905
WASHC4 WASH complex subunit 4 -2.89837
IGFBP7 insulin-like growth factor binding protein 7 -2.8359
CD58 CD58 molecule -2.70188
SH3D19 SH3 domain containing 19 -2.64372
VDAC1 voltage-dependent anion channel 1 -2.56726
TUBA4A tubulin, alpha 4a -2.46997
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.24199
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.08483