CRCGN016_MCF10A.TP53.M_24H:G02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description theophylline 33.99 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 3.96143
SPAG4 sperm associated antigen 4 3.8209
MEST mesoderm specific transcript 3.47399
ADRB2 adrenoceptor beta 2, surface 2.65703
ACAA1 acetyl-CoA acyltransferase 1 2.60697
PPOX protoporphyrinogen oxidase 2.55679
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.51486
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.51329
ZNF318 zinc finger protein 318 2.45159
COMP cartilage oligomeric matrix protein 2.33441
PMM2 phosphomannomutase 2 2.32788
CADM1 cell adhesion molecule 1 2.28261
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.17493
TXNL4B thioredoxin-like 4B 2.16323
MPST mercaptopyruvate sulfurtransferase 2.16053
GARRE1 granule associated Rac and RHOG effector 1 2.15423
KLHDC3 kelch domain containing 3 2.1292
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 2.10692
ATG101 autophagy related 101 2.0883
THOC6 THO complex 6 2.05209
CD19 CD19 molecule 2.05178
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.01647
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.01555
CIAO3 cytosolic iron-sulfur assembly component 3 2.00403

decreased expression

Symbol Name Standardized Value
UBE3C ubiquitin protein ligase E3C -4.47873
TUBB6 tubulin, beta 6 class V -4.03933
TIMP1 TIMP metallopeptidase inhibitor 1 -3.82842
MRPS7 mitochondrial ribosomal protein S7 -3.41813
NUP85 nucleoporin 85kDa -3.22709
ATP5PD ATP synthase peripheral stalk subunit d -3.0893
TRAPPC3 trafficking protein particle complex 3 -3.08224
REEP5 receptor accessory protein 5 -3.01443
DSG2 desmoglein 2 -2.84679
JPT1 Jupiter microtubule associated homolog 1 -2.83415
ANXA2 annexin A2 -2.81731
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.72047
GOLT1B golgi transport 1B -2.65173
S100A11 S100 calcium binding protein A11 -2.62043
OXA1L oxidase (cytochrome c) assembly 1-like -2.49485
H3-3B H3.3 histone B -2.47518
XPO7 exportin 7 -2.40912
SUMO4 small ubiquitin-like modifier 4 -2.34482
BASP1 brain abundant, membrane attached signal protein 1 -2.32262
MRPL58 mitochondrial ribosomal protein L58 -2.30474
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.23378
UBE2A ubiquitin-conjugating enzyme E2A -2.22524
LRP10 low density lipoprotein receptor-related protein 10 -2.19522
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.1913
SAP30BP SAP30 binding protein -2.17411
LDHD lactate dehydrogenase D -2.16592
CD320 CD320 molecule -2.07138
CEMIP2 cell migration inducing hyaluronidase 2 -2.07033
ANKRD10 ankyrin repeat domain 10 -2.04693
GRB2 growth factor receptor-bound protein 2 -2.04654
VAT1 vesicle amine transport 1 -2.04462
IGFBP7 insulin-like growth factor binding protein 7 -2.03256