CRCGN016_MCF10A.TP53.M_24H:G03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description theophylline 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.25188
CCDC85B coiled-coil domain containing 85B 4.94511
ACAA1 acetyl-CoA acyltransferase 1 3.48994
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.97665
SPAG4 sperm associated antigen 4 2.95945
ATG101 autophagy related 101 2.71574
UBXN6 UBX domain protein 6 2.59758
PMM2 phosphomannomutase 2 2.49558
GUK1 guanylate kinase 1 2.45067
DENND2D DENN/MADD domain containing 2D 2.36093
MTMR14 myotubularin related protein 14 2.34649
COMP cartilage oligomeric matrix protein 2.3341
CDC34 cell division cycle 34 2.26299
INTS15 integrator complex subunit 15 2.24656
EDN1 endothelin 1 2.22032
PXDC1 PX domain containing 1 2.14828
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.13733
MELK maternal embryonic leucine zipper kinase 2.1262
TSSC4 tumor suppressing subtransferable candidate 4 2.10073
AMPD2 adenosine monophosphate deaminase 2 2.09924
MCRS1 microspherule protein 1 2.07579
COG2 component of oligomeric golgi complex 2 2.05632
STRN4 striatin, calmodulin binding protein 4 2.04386
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.04144
WDR46 WD repeat domain 46 2.04019

decreased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 -5.24285
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.22891
PUF60 poly-U binding splicing factor 60KDa -3.49252
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.48365
HAT1 histone acetyltransferase 1 -3.29367
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.087
PSIP1 PC4 and SFRS1 interacting protein 1 -2.98439
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.91075
TXNRD1 thioredoxin reductase 1 -2.5569
IQGAP1 IQ motif containing GTPase activating protein 1 -2.30731
PCNA proliferating cell nuclear antigen -2.23818
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.20672
TGFBR3 transforming growth factor, beta receptor III -2.19351
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.10406
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.1029
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.04278
TFG TRK-fused gene -2.0236
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.02251
FMO1 flavin containing monooxygenase 1 -2.00427
OXA1L oxidase (cytochrome c) assembly 1-like -2.00175
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.00059