CRCGN016_MCF10A.TP53.M_24H:G06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description alpha-methyldopa sesquihydrate 11.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

35 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 8.81717
GPER1 G protein-coupled estrogen receptor 1 4.93659
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 3.24865
NEFM neurofilament, medium polypeptide 2.84772
ACAA1 acetyl-CoA acyltransferase 1 2.74602
SYT1 synaptotagmin I 2.73085
STMN2 stathmin 2 2.65226
NEFL neurofilament, light polypeptide 2.63671
CADPS2 Ca++-dependent secretion activator 2 2.62624
LGI1 leucine-rich, glioma inactivated 1 2.50371
SCG3 secretogranin III 2.34667
SYN1 synapsin I 2.32728
SNAP91 synaptosomal-associated protein, 91kDa 2.29863
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.26859
VSNL1 visinin-like 1 2.26692
CCL1 chemokine (C-C motif) ligand 1 2.17991
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.17137
TPH1 tryptophan hydroxylase 1 2.11709
CLEC1A C-type lectin domain family 1, member A 2.09532
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.09406
SULT4A1 sulfotransferase family 4A, member 1 2.05684
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.02061
NABP2 nucleic acid binding protein 2 2.02054
FBXO5 F-box protein 5 2.01477

decreased expression

Symbol Name Standardized Value
TEX10 testis expressed 10 -5.21988
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.10478
PCNA proliferating cell nuclear antigen -4.68754
PARP2 poly (ADP-ribose) polymerase 2 -3.16761
SNRPB2 small nuclear ribonucleoprotein polypeptide B -3.07089
THAP11 THAP domain containing 11 -2.75749
GRN granulin -2.44174
MSN moesin -2.3263
BRD7 bromodomain containing 7 -2.16476
EXT2 exostosin glycosyltransferase 2 -2.15344
MB myoglobin -2.10314