CRCGN016_MCF10A.TP53.M_24H:G07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 97.94 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

155 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 4.86027
PEX11A peroxisomal biogenesis factor 11 alpha 3.98988
ABHD6 abhydrolase domain containing 6 3.49986
GLRX glutaredoxin (thioltransferase) 3.41884
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.26297
NUCB2 nucleobindin 2 3.1979
ACAA1 acetyl-CoA acyltransferase 1 3.11802
SNAP25 synaptosomal-associated protein, 25kDa 3.0514
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.05123
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.98793
AXIN1 axin 1 2.90136
MEST mesoderm specific transcript 2.82981
TRIB3 tribbles pseudokinase 3 2.68722
KRT81 keratin 81, type II 2.64624
IL15RA interleukin 15 receptor, alpha 2.63716
ANKH ANKH inorganic pyrophosphate transport regulator 2.63008
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.62621
NDE1 nudE neurodevelopment protein 1 2.45061
COMP cartilage oligomeric matrix protein 2.43594
PRAF2 PRA1 domain family, member 2 2.40297
BDKRB1 bradykinin receptor B1 2.36955
S100A4 S100 calcium binding protein A4 2.36836
PRODH2 proline dehydrogenase (oxidase) 2 2.34404
HMGA2 high mobility group AT-hook 2 2.32567
DENND2D DENN/MADD domain containing 2D 2.32379
PHGDH phosphoglycerate dehydrogenase 2.30487
ANPEP alanyl (membrane) aminopeptidase 2.29348
FICD FIC domain containing 2.29014
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.26936
AQP7 aquaporin 7 2.26931
ECH1 enoyl CoA hydratase 1, peroxisomal 2.26173
LGMN legumain 2.19626
LMAN1L lectin, mannose-binding, 1 like 2.19051
MXD3 MAX dimerization protein 3 2.17791
ND5 NADH dehydrogenase subunit 5 2.17126
BDKRB2 bradykinin receptor B2 2.16526
CYBC1 cytochrome b-245 chaperone 1 2.15208
STAG3 stromal antigen 3 2.14235
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.13983
SCPEP1 serine carboxypeptidase 1 2.12648
SERHL2 serine hydrolase-like 2 2.12063
STX4 syntaxin 4 2.11507
DPYS dihydropyrimidinase 2.11361
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.10102
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.0988
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.09796
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.09719
PAQR4 progestin and adipoQ receptor family member IV 2.09181
PNPLA3 patatin-like phospholipase domain containing 3 2.08477
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.07808
CD19 CD19 molecule 2.073
CIRSR corepressor of RBPJ and splicing regulator 2.06334
ARHGAP25 Rho GTPase activating protein 25 2.03399
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.03154
CIB1 calcium and integrin binding 1 (calmyrin) 2.00532

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -4.46716
GRWD1 glutamate-rich WD repeat containing 1 -4.24726
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.05021
FASTKD5 FAST kinase domains 5 -3.90075
MRPS2 mitochondrial ribosomal protein S2 -3.83543
MAPK13 mitogen-activated protein kinase 13 -3.73948
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.67952
PFN1 profilin 1 -3.59656
STMN1 stathmin 1 -3.50823
RPS5 ribosomal protein S5 -3.36077
CDC45 cell division cycle 45 -3.2931
RPL18 ribosomal protein L18 -3.17811
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -3.00118
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.98318
GADD45B growth arrest and DNA-damage-inducible, beta -2.84674
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.82335
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.82071
ZNF551 zinc finger protein 551 -2.66989
RBM14-RBM4 RBM14-RBM4 readthrough -2.64197
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.63348
ALG9 ALG9, alpha-1,2-mannosyltransferase -2.55881
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.55157
NAT10 N-acetyltransferase 10 (GCN5-related) -2.54799
NOSIP nitric oxide synthase interacting protein -2.54191
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.52775
ADRB2 adrenoceptor beta 2, surface -2.50515
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -2.46451
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.46338
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -2.45735
ZNF134 zinc finger protein 134 -2.44631
EHD4 EH-domain containing 4 -2.44031
PMPCA peptidase (mitochondrial processing) alpha -2.42408
TSC22D3 TSC22 domain family, member 3 -2.42212
PRR15L proline rich 15-like -2.41861
ENDOG endonuclease G -2.38274
OXCT1 3-oxoacid CoA transferase 1 -2.36306
EIF3I eukaryotic translation initiation factor 3, subunit I -2.35953
RPL36A ribosomal protein L36a -2.3548
RPL35 ribosomal protein L35 -2.34291
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.32989
RAB11FIP1 RAB11 family interacting protein 1 (class I) -2.32594
SLC44A4 solute carrier family 44, member 4 -2.29491
PPID peptidylprolyl isomerase D -2.28941
BCL7B B-cell CLL/lymphoma 7B -2.28446
HSPA1A heat shock 70kDa protein 1A -2.27417
PRCP prolylcarboxypeptidase (angiotensinase C) -2.27319
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.26671
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.26318
RNASE7 ribonuclease, RNase A family, 7 -2.25644
RPL11 ribosomal protein L11 -2.25445
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -2.24449
GLO1 glyoxalase I -2.2359
NCBP3 nuclear cap binding subunit 3 -2.2315
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.22293
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -2.2217
PCCB propionyl CoA carboxylase, beta polypeptide -2.2173
ZNF211 zinc finger protein 211 -2.20506
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.19677
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -2.1924
CRY1 cryptochrome circadian clock 1 -2.18342
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.1582
NUBPL nucleotide binding protein-like -2.14944
SEC16A SEC16 homolog A (S. cerevisiae) -2.14834
RPS19 ribosomal protein S19 -2.14295
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.13429
ADGRF5 adhesion G protein-coupled receptor F5 -2.12646
FRS2 fibroblast growth factor receptor substrate 2 -2.12493
PRPF4 pre-mRNA processing factor 4 -2.11875
TUBB4B tubulin, beta 4B class IVb -2.10582
CCNB2 cyclin B2 -2.10131
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.09536
SNRPC small nuclear ribonucleoprotein polypeptide C -2.09257
NLRP2B NLR family pyrin domain containing 2B -2.08806
TMEM38B transmembrane protein 38B -2.08452
NELFB negative elongation factor complex member B -2.07908
HEATR3 HEAT repeat containing 3 -2.07096
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.07069
RPLP2 ribosomal protein, large, P2 -2.07014
HAPSTR1 HUWE1 associated protein modifying stress responses -2.06722
PAEP progestagen-associated endometrial protein -2.0668
MCM3 minichromosome maintenance complex component 3 -2.06547
INTS12 integrator complex subunit 12 -2.06406
RPL8 ribosomal protein L8 -2.06297
PIERCE1 piercer of microtubule wall 1 -2.06192
COMMD1 copper metabolism (Murr1) domain containing 1 -2.05846
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.05405
ECD ecdysoneless homolog (Drosophila) -2.05054
RGS2 regulator of G-protein signaling 2 -2.04866
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.04053
OXSR1 oxidative stress responsive 1 -2.03879
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.03688
OXA1L oxidase (cytochrome c) assembly 1-like -2.02443
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.02307
LBR lamin B receptor -2.02189
RPS29 ribosomal protein S29 -2.01325
RPL18A ribosomal protein L18a -2.0091
DCTN5 dynactin 5 (p25) -2.00893
DMAC2 distal membrane arm assembly component 2 -2.00679
URM1 ubiquitin related modifier 1 -2.00624
PGCKA1 PDCD10 and GCKIII kinases associated 1 -2.00371