CRCGN016_MCF10A.TP53.M_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 10.88 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 3.35909
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.29918
CIAO3 cytosolic iron-sulfur assembly component 3 3.29142
ACAA1 acetyl-CoA acyltransferase 1 3.12973
CNRIP1 cannabinoid receptor interacting protein 1 2.99507
COMP cartilage oligomeric matrix protein 2.80544
SPAG4 sperm associated antigen 4 2.72664
NUTF2 nuclear transport factor 2 2.39994
RIC8A RIC8 guanine nucleotide exchange factor A 2.3126
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.25728
NFS1 NFS1 cysteine desulfurase 2.19992
SIRT3 sirtuin 3 2.17037
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.15205
MRPS15 mitochondrial ribosomal protein S15 2.05473
WDR76 WD repeat domain 76 2.0403
ERGIC2 ERGIC and golgi 2 2.02616

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.32129
RPIA ribose 5-phosphate isomerase A -4.01694
TEX10 testis expressed 10 -3.81669
TM9SF3 transmembrane 9 superfamily member 3 -3.25427
HSPA8 heat shock 70kDa protein 8 -3.19994
SGK1 serum/glucocorticoid regulated kinase 1 -3.11208
ENOPH1 enolase-phosphatase 1 -2.99525
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.44642
CCNB1 cyclin B1 -2.44053
TRIM36 tripartite motif containing 36 -2.25122
NRIP1 nuclear receptor interacting protein 1 -2.22531
RBM15B RNA binding motif protein 15B -2.17174
RALGDS ral guanine nucleotide dissociation stimulator -2.13725
MFSD12 major facilitator superfamily domain containing 12 -2.09687
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.0158
MUC6 mucin 6, oligomeric mucus/gel-forming -2.00735