CRCGN016_MCF10A.TP53.M_24H:G16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 10.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 4.4237
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.81293
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.80398
HMGA2 high mobility group AT-hook 2 3.76472
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.62547
SCCPDH saccharopine dehydrogenase (putative) 3.53383
FHL2 four and a half LIM domains 2 3.48035
SQSTM1 sequestosome 1 3.29143
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.12431
ZNF586 zinc finger protein 586 3.02775
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.91624
CXCL2 chemokine (C-X-C motif) ligand 2 2.72142
CBR1 carbonyl reductase 1 2.64923
CDCA4 cell division cycle associated 4 2.62113
TNIP1 TNFAIP3 interacting protein 1 2.60523
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.52667
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.45745
WIF1 WNT inhibitory factor 1 2.41195
TSPAN4 tetraspanin 4 2.40381
PRAF2 PRA1 domain family, member 2 2.3931
TMEM50A transmembrane protein 50A 2.38445
SIL1 SIL1 nucleotide exchange factor 2.32145
TCTN1 tectonic family member 1 2.31912
DUSP4 dual specificity phosphatase 4 2.30921
SPHK1 sphingosine kinase 1 2.29598
SQOR sulfide quinone oxidoreductase 2.29404
CUEDC2 CUE domain containing 2 2.22889
CIRBP cold inducible RNA binding protein 2.22034
FOSL1 FOS-like antigen 1 2.20877
EGR1 early growth response 1 2.20204
CHIC2 cysteine-rich hydrophobic domain 2 2.20104
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.19619
LRP10 low density lipoprotein receptor-related protein 10 2.16493
IFI6 interferon, alpha-inducible protein 6 2.1574
GCLM glutamate-cysteine ligase, modifier subunit 2.15047
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.15026
TLCD3A TLC domain containing 3A 2.14592
CTSL cathepsin L 2.13863
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.13501
CETN3 centrin, EF-hand protein, 3 2.09457
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.07138
ATRAID all-trans retinoic acid-induced differentiation factor 2.05545
DENND2D DENN/MADD domain containing 2D 2.03055

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.70311
DDIT4 DNA-damage-inducible transcript 4 -5.21595
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.12372
PRR15L proline rich 15-like -4.3962
COG2 component of oligomeric golgi complex 2 -3.99454
TXNDC9 thioredoxin domain containing 9 -3.74748
HSPB1 heat shock 27kDa protein 1 -3.72134
TSC22D3 TSC22 domain family, member 3 -3.54154
INSIG1 insulin induced gene 1 -3.49934
NT5DC2 5'-nucleotidase domain containing 2 -3.36024
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -3.20432
ANKRD10 ankyrin repeat domain 10 -2.99534
TUBA4A tubulin, alpha 4a -2.98141
CORO1A coronin, actin binding protein, 1A -2.96291
PDCD10 programmed cell death 10 -2.91307
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.8586
DCK deoxycytidine kinase -2.81309
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.6911
RGS2 regulator of G-protein signaling 2 -2.67405
S100A4 S100 calcium binding protein A4 -2.66577
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.6393
STAP2 signal transducing adaptor family member 2 -2.58994
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.51329
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.50758
MFAP4 microfibrillar-associated protein 4 -2.47723
GTF2A2 general transcription factor IIA, 2, 12kDa -2.42582
ORC4 origin recognition complex, subunit 4 -2.40347
LBR lamin B receptor -2.39979
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.38044
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.36439
ALDOC aldolase C, fructose-bisphosphate -2.35489
OXSR1 oxidative stress responsive 1 -2.32516
EXOC1 exocyst complex component 1 -2.31552
TOB1 transducer of ERBB2, 1 -2.29756
CYCS cytochrome c, somatic -2.2613
SESN1 sestrin 1 -2.23789
PAX9 paired box 9 -2.23571
CAPN1 calpain 1, (mu/I) large subunit -2.23363
ATG4A autophagy related 4A, cysteine peptidase -2.23068
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.22707
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.21468
CLIC3 chloride intracellular channel 3 -2.21207
COMMD8 COMM domain containing 8 -2.2041
SLC25A46 solute carrier family 25, member 46 -2.19397
AACS acetoacetyl-CoA synthetase -2.18133
ACLY ATP citrate lyase -2.17868
ZNF274 zinc finger protein 274 -2.1653
NLRP2B NLR family pyrin domain containing 2B -2.15598
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -2.15517
MPC1 mitochondrial pyruvate carrier 1 -2.1392
KRT24 keratin 24, type I -2.1258
MEIS1 Meis homeobox 1 -2.08331
LIPT1 lipoyltransferase 1 -2.05615
KRT13 keratin 13, type I -2.04163
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.03853
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.01121
PGAM4 phosphoglycerate mutase family member 4 -2.01048
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.00772
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.00753
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.00065