CRCGN016_MCF10A.TP53.M_24H:G21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-nitrothiazole 10.7 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:G21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 9.40996
RPL39L ribosomal protein L39-like 4.95148
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.66162
FZD7 frizzled class receptor 7 3.92157
NRBF2 nuclear receptor binding factor 2 3.58476
ALOX15 arachidonate 15-lipoxygenase 3.5016
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.9252
XAB2 XPA binding protein 2 2.80328
RNF4 ring finger protein 4 2.6446
COMP cartilage oligomeric matrix protein 2.60787
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.58997
PEX12 peroxisomal biogenesis factor 12 2.58266
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.53999
TRIM68 tripartite motif containing 68 2.50163
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.37131
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 2.36845
TBC1D31 TBC1 domain family, member 31 2.33567
CHEK2 checkpoint kinase 2 2.31309
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.31101
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.30793
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.30579
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.27767
THAP10 THAP domain containing 10 2.25741
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.25488
IGFBP6 insulin-like growth factor binding protein 6 2.24772
SH3BP4 SH3-domain binding protein 4 2.22473
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.21799
BACE1 beta-site APP-cleaving enzyme 1 2.19585
CRTC3 CREB regulated transcription coactivator 3 2.16851
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.15155
DCLRE1A DNA cross-link repair 1A 2.14673
MVB12B multivesicular body subunit 12B 2.13588
MTMR2 myotubularin related protein 2 2.10153
RYR1 ryanodine receptor 1 (skeletal) 2.09786
LOC124907782 dual specificity protein phosphatase 22 2.09115
DPF2 D4, zinc and double PHD fingers family 2 2.08782
ARHGAP19 Rho GTPase activating protein 19 2.0824
WDR1 WD repeat domain 1 2.07804
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.07211
MB myoglobin 2.06157
APOO apolipoprotein O 2.05642
ACTA2 actin, alpha 2, smooth muscle, aorta 2.04204
AKAP3 A kinase (PRKA) anchor protein 3 2.04191
PTER phosphotriesterase related 2.04068
FAN1 FANCD2/FANCI-associated nuclease 1 2.01415
TDP1 tyrosyl-DNA phosphodiesterase 1 2.01408

decreased expression

Symbol Name Standardized Value
CDC45 cell division cycle 45 -4.97625
TRAPPC3 trafficking protein particle complex 3 -4.84787
MRPS16 mitochondrial ribosomal protein S16 -4.54402
LUC7L LUC7-like (S. cerevisiae) -4.47045
BASP1 brain abundant, membrane attached signal protein 1 -4.23694
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.99588
MRPS15 mitochondrial ribosomal protein S15 -3.22485
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.18577
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.83869
TEDC2 tubulin epsilon and delta complex 2 -2.71149
DLK2 delta-like 2 homolog (Drosophila) -2.66403
MICU1 mitochondrial calcium uptake 1 -2.62304
PGAP6 post-GPI attachment to proteins 6 -2.61198
RHOT2 ras homolog family member T2 -2.55072
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.46457
RND3 Rho family GTPase 3 -2.44028
OSBPL10 oxysterol binding protein-like 10 -2.43005
WDR6 WD repeat domain 6 -2.41971
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.41774
SRPK1 SRSF protein kinase 1 -2.39459
INO80D INO80 complex subunit D -2.3917
PRRX1 paired related homeobox 1 -2.38631
MCFD2 multiple coagulation factor deficiency 2 -2.3744
MMP17 matrix metallopeptidase 17 (membrane-inserted) -2.36925
QTRT1 queuine tRNA-ribosyltransferase 1 -2.35653
MACO1 macoilin 1 -2.34307
VPREB3 pre-B lymphocyte 3 -2.33701
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.33109
GPR6 G protein-coupled receptor 6 -2.32016
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.31596
PNRC1 proline-rich nuclear receptor coactivator 1 -2.31277
HPCA hippocalcin -2.28489
NEUROD6 neuronal differentiation 6 -2.27895
HBZ hemoglobin, zeta -2.2702
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.25722
CP ceruloplasmin (ferroxidase) -2.25237
LY6G6C lymphocyte antigen 6 complex, locus G6C -2.2352
GRIA2 glutamate receptor, ionotropic, AMPA 2 -2.23489
CASP5 caspase 5, apoptosis-related cysteine peptidase -2.2345
TNMD tenomodulin -2.22912
CD79B CD79b molecule, immunoglobulin-associated beta -2.2287
AGTR1 angiotensin II receptor, type 1 -2.21186
CRYBG2 crystallin beta-gamma domain containing 2 -2.21178
VSIG10 V-set and immunoglobulin domain containing 10 -2.21009
CHAD chondroadherin -2.20325
RNF144A ring finger protein 144A -2.202
SNPH syntaphilin -2.19861
BTG3 BTG family, member 3 -2.19237
BOLA2B bolA family member 2B -2.18995
IFT20 intraflagellar transport 20 -2.183
RAG1 recombination activating gene 1 -2.18263
RASL10A RAS-like, family 10, member A -2.17502
PSG11 pregnancy specific beta-1-glycoprotein 11 -2.17118
ALS2CL ALS2 C-terminal like -2.16445
CLDN9 claudin 9 -2.16153
TAC1 tachykinin, precursor 1 -2.15245
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.14933
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 -2.14676
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.12949
ZMYM4 zinc finger, MYM-type 4 -2.12484
UPK1A uroplakin 1A -2.12334
CALB2 calbindin 2 -2.12209
NPAS2 neuronal PAS domain protein 2 -2.11259
KLRG1 killer cell lectin-like receptor subfamily G, member 1 -2.10602
FLCN folliculin -2.10463
NTHL1 nth endonuclease III-like 1 (E. coli) -2.09995
GOLGA4 golgin A4 -2.09309
MMP11 matrix metallopeptidase 11 -2.08968
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 -2.08529
SEM1 SEM1 26S proteasome subunit -2.083
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.08158
NOTCH4 notch 4 -2.07449
FOLR3 folate receptor 3 (gamma) -2.07432
ZNF506 zinc finger protein 506 -2.06605
ATP11B ATPase, class VI, type 11B -2.0534
SLC22A14 solute carrier family 22, member 14 -2.05325
ZNF91 zinc finger protein 91 -2.0489
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.04204
SNX2 sorting nexin 2 -2.04198
CRELD1 cysteine-rich with EGF-like domains 1 -2.03795
CAPN2 calpain 2, (m/II) large subunit -2.03304
COL9A1 collagen, type IX, alpha 1 -2.02355
PCDHGA3 protocadherin gamma subfamily A, 3 -2.02085
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 -2.01782
FGL1 fibrinogen-like 1 -2.01424
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -2.01383
HMHB1 histocompatibility (minor) HB-1 -2.00594
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.00187