CRCGN016_MCF10A.TP53.M_24H:H01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 102.48 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 3.79356
SPAG4 sperm associated antigen 4 3.17512
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.1407
TBX2 T-box 2 2.7912
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.72895
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.37677
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.37455
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.36745
PTCD1 pentatricopeptide repeat domain 1 2.35543
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.22887
MCUR1 mitochondrial calcium uniporter regulator 1 2.22195
CTBP2 C-terminal binding protein 2 2.21348
STARD7 StAR-related lipid transfer (START) domain containing 7 2.1499
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 2.09381
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.084
MNS1 meiosis-specific nuclear structural 1 2.03875
AKR1C3 aldo-keto reductase family 1, member C3 2.00706

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -4.93679
KRT14 keratin 14, type I -4.91823
MSN moesin -3.74185
DSG2 desmoglein 2 -3.64347
HMG20B high mobility group 20B -3.39632
MRPS16 mitochondrial ribosomal protein S16 -3.11666
TMEM258 transmembrane protein 258 -3.00778
GTPBP8 GTP-binding protein 8 (putative) -2.92341
JMJD6 jumonji domain containing 6 -2.88681
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.84431
SEC61G Sec61 gamma subunit -2.81887
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -2.74186
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.52878
SH3D19 SH3 domain containing 19 -2.33028
NRIP1 nuclear receptor interacting protein 1 -2.31881
RPL36 ribosomal protein L36 -2.30824
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.28473
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.2668
COX17 COX17 cytochrome c oxidase copper chaperone -2.25403
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.22217
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.19678
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.19274
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.18878
RCN1 reticulocalbin 1, EF-hand calcium binding domain -2.15425
FBXL4 F-box and leucine-rich repeat protein 4 -2.14901
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.10522
ATP5F1E ATP synthase F1 subunit epsilon -2.0943
MACF1 microtubule-actin crosslinking factor 1 -2.08114
ATP5PD ATP synthase peripheral stalk subunit d -2.06712
SAP30BP SAP30 binding protein -2.04894