CRCGN016_MCF10A.TP53.M_24H:H02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 34.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 3.9505
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.65
ABHD6 abhydrolase domain containing 6 3.55259
ACAA1 acetyl-CoA acyltransferase 1 2.80374
FGFR4 fibroblast growth factor receptor 4 2.61251
SIRT3 sirtuin 3 2.26743
RIC8A RIC8 guanine nucleotide exchange factor A 2.24279
HBA1 hemoglobin, alpha 1 2.21831
DEAF1 DEAF1 transcription factor 2.21273
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.18957
CCNA1 cyclin A1 2.11527
FXYD2 FXYD domain containing ion transport regulator 2 2.07753

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -4.22864
BAG3 BCL2-associated athanogene 3 -4.14805
ADI1 acireductone dioxygenase 1 -3.22957
MRPS16 mitochondrial ribosomal protein S16 -3.1838
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.07763
THAP11 THAP domain containing 11 -3.04768
HEATR1 HEAT repeat containing 1 -2.90682
BASP1 brain abundant, membrane attached signal protein 1 -2.47899
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.11127
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.10924
IGFBP7 insulin-like growth factor binding protein 7 -2.10416
NOSIP nitric oxide synthase interacting protein -2.08457
ANXA2 annexin A2 -2.02403