CRCGN016_MCF10A.TP53.M_24H:H03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene 11.39 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 4.357
VAV3 vav 3 guanine nucleotide exchange factor 3.76729
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.34473
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.32099
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.26836
GATA3 GATA binding protein 3 2.8978
VGLL4 vestigial-like family member 4 2.77294
CAPN7 calpain 7 2.45913
EXOC1 exocyst complex component 1 2.30627
SATB1 SATB homeobox 1 2.1958
ACAA1 acetyl-CoA acyltransferase 1 2.09823
MMP1 matrix metallopeptidase 1 2.08375
HDAC3 histone deacetylase 3 2.01309
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.00206

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -4.66535
PGAM4 phosphoglycerate mutase family member 4 -4.44425
MPC2 mitochondrial pyruvate carrier 2 -4.42934
SCYL3 SCY1-like 3 (S. cerevisiae) -4.08739
TOR1A torsin family 1, member A (torsin A) -3.93233
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.61197
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.32998
KDM3A lysine (K)-specific demethylase 3A -3.24085
IGFBP7 insulin-like growth factor binding protein 7 -2.89323
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.76127
TOR1B torsin family 1, member B (torsin B) -2.67605
PIH1D1 PIH1 domain containing 1 -2.63006
MKKS McKusick-Kaufman syndrome -2.609
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.522
KRT14 keratin 14, type I -2.40801
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -2.29205
TBC1D12 TBC1 domain family, member 12 -2.25037
PGK1 phosphoglycerate kinase 1 -2.23886
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.21723
CAPN2 calpain 2, (m/II) large subunit -2.21306
USP20 ubiquitin specific peptidase 20 -2.20985
KIF14 kinesin family member 14 -2.20883
CUEDC1 CUE domain containing 1 -2.18628
CCL23 chemokine (C-C motif) ligand 23 -2.10056
ADGRG3 adhesion G protein-coupled receptor G3 -2.08272
SATB2 SATB homeobox 2 -2.05326