CRCGN016_MCF10A.TP53.M_24H:H04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-nitroaniline 100.46 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.67865
CXCR4 chemokine (C-X-C motif) receptor 4 3.6348
MCOLN1 mucolipin 1 3.61281
ZNF586 zinc finger protein 586 3.58736
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.42545
MAMLD1 mastermind-like domain containing 1 3.18464
CADM1 cell adhesion molecule 1 2.97758
E2F2 E2F transcription factor 2 2.82522
PNPLA6 patatin-like phospholipase domain containing 6 2.5362
CCL2 chemokine (C-C motif) ligand 2 2.53303
TRIB3 tribbles pseudokinase 3 2.51829
CHN1 chimerin 1 2.47686
ARID5B AT rich interactive domain 5B (MRF1-like) 2.43068
QTRT1 queuine tRNA-ribosyltransferase 1 2.41894
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.39869
PPOX protoporphyrinogen oxidase 2.35327
H2BC12 H2B clustered histone 12 2.34752
PILRB paired immunoglobin-like type 2 receptor beta 2.30833
WBP2 WW domain binding protein 2 2.29061
ALDOC aldolase C, fructose-bisphosphate 2.28706
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.27761
MOGS mannosyl-oligosaccharide glucosidase 2.27653
H2AC7 H2A clustered histone 7 2.26618
THBS3 thrombospondin 3 2.25892
SLCO4A1 solute carrier organic anion transporter family, member 4A1 2.2492
SYNE2 spectrin repeat containing, nuclear envelope 2 2.2224
THOC6 THO complex 6 2.21883
ZNF671 zinc finger protein 671 2.20271
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.19148
CCL7 chemokine (C-C motif) ligand 7 2.17462
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.17065
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.16554
RPAP1 RNA polymerase II associated protein 1 2.11501
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.10731
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.10233
MSH5 mutS homolog 5 2.08582
FBXL12 F-box and leucine-rich repeat protein 12 2.07507
MARCHF8 membrane associated ring-CH-type finger 8 2.07504
PCDHGA3 protocadherin gamma subfamily A, 3 2.07475
SREBF2 sterol regulatory element binding transcription factor 2 2.07348
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.07255
REC8 REC8 meiotic recombination protein 2.07202
CEP170B centrosomal protein 170B 2.06873
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 2.05887
WDR13 WD repeat domain 13 2.05749
CPTP ceramide-1-phosphate transfer protein 2.05108
ZNF358 zinc finger protein 358 2.04862
PCDHB6 protocadherin beta 6 2.04721
OSBPL10 oxysterol binding protein-like 10 2.03159
ACP5 acid phosphatase 5, tartrate resistant 2.02115

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -4.86109
HSPA1A heat shock 70kDa protein 1A -4.14733
BAG3 BCL2-associated athanogene 3 -4.14059
IGFBP7 insulin-like growth factor binding protein 7 -4.03571
LDHD lactate dehydrogenase D -3.85909
PIH1D1 PIH1 domain containing 1 -3.85774
DYNLT3 dynein, light chain, Tctex-type 3 -3.85225
ANXA2 annexin A2 -3.7764
HEATR1 HEAT repeat containing 1 -3.73596
TOR1A torsin family 1, member A (torsin A) -3.43273
COTL1 coactosin-like F-actin binding protein 1 -3.17187
CCNB2 cyclin B2 -3.17114
BCAP29 B-cell receptor-associated protein 29 -3.05419
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.98726
HSPA8 heat shock 70kDa protein 8 -2.98123
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.91781
TMEM168 transmembrane protein 168 -2.854
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.72251
TUBB6 tubulin, beta 6 class V -2.65351
EFHD2 EF-hand domain family, member D2 -2.62005
TIPIN TIMELESS interacting protein -2.61162
GLTP glycolipid transfer protein -2.58006
NUSAP1 nucleolar and spindle associated protein 1 -2.54013
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.4814
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.47247
PCNA proliferating cell nuclear antigen -2.42137
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.41852
FASTKD5 FAST kinase domains 5 -2.32114
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.24317
CDC42SE1 CDC42 small effector 1 -2.23439
OBI1 ORC ubiquitin ligase 1 -2.23318
TOR1AIP2 torsin A interacting protein 2 -2.21098
POLR1G RNA polymerase I subunit G -2.20321
TMEM109 transmembrane protein 109 -2.19613
LMO2 LIM domain only 2 (rhombotin-like 1) -2.19101
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.14987
STMN1 stathmin 1 -2.14271
COG5 component of oligomeric golgi complex 5 -2.13881
CTSZ cathepsin Z -2.12915
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.12453
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.1149
CDCA4 cell division cycle associated 4 -2.10673
MCM3 minichromosome maintenance complex component 3 -2.10516
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.10284
RFC2 replication factor C (activator 1) 2, 40kDa -2.09496
TRIM32 tripartite motif containing 32 -2.06267
SLC35F2 solute carrier family 35, member F2 -2.0544
DCK deoxycytidine kinase -2.05295
MSN moesin -2.0442
EMID1 EMI domain containing 1 -2.00761