CRCGN016_MCF10A.TP53.M_24H:H06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-nitroaniline 11.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HYOU1 hypoxia up-regulated 1 5.13898
PPARG peroxisome proliferator-activated receptor gamma 4.55621
ADGRE5 adhesion G protein-coupled receptor E5 4.49395
IDE insulin-degrading enzyme 3.65687
SNAP25 synaptosomal-associated protein, 25kDa 3.63797
KLHL21 kelch-like family member 21 3.56536
MMP1 matrix metallopeptidase 1 2.96319
ILK integrin-linked kinase 2.79615
CERK ceramide kinase 2.65824
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.63173
TXNL4B thioredoxin-like 4B 2.35443
SPAG4 sperm associated antigen 4 2.35279
MELK maternal embryonic leucine zipper kinase 2.12573
NFE2L2 nuclear factor, erythroid 2-like 2 2.05076

decreased expression

Symbol Name Standardized Value
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.03848
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.88031
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.2811
PRPF38B pre-mRNA processing factor 38B -2.32826
MPC2 mitochondrial pyruvate carrier 2 -2.32621
KIFBP kinesin family binding protein -2.31994
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.19938
LY86 lymphocyte antigen 86 -2.19721
NCBP3 nuclear cap binding subunit 3 -2.16611
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.10999
WASHC4 WASH complex subunit 4 -2.0944