CRCGN016_MCF10A.TP53.M_24H:H15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description barium chloride dihydrate 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 4.98714
CRELD2 cysteine-rich with EGF-like domains 2 4.86802
TBX2 T-box 2 4.58911
CXCR4 chemokine (C-X-C motif) receptor 4 4.53257
GATD3 glutamine amidotransferase class 1 domain containing 3 4.41664
KDM5D lysine (K)-specific demethylase 5D 4.30197
HBA1 hemoglobin, alpha 1 4.226
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.89527
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.57275
VGLL4 vestigial-like family member 4 3.54867
HBB hemoglobin, beta 3.34818
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 3.32284
PFKL phosphofructokinase, liver 3.20106
USP9Y ubiquitin specific peptidase 9, Y-linked 3.12175
SPDEF SAM pointed domain containing ETS transcription factor 2.90306
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.86415
CADM1 cell adhesion molecule 1 2.85363
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.74137
TRAPPC10 trafficking protein particle complex 10 2.69967
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.51409
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.50969
KDM1A lysine (K)-specific demethylase 1A 2.49316
FZD7 frizzled class receptor 7 2.45135
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.33697
PLXNB2 plexin B2 2.28502
NDC80 NDC80 kinetochore complex component 2.26723
PECR peroxisomal trans-2-enoyl-CoA reductase 2.22003
RAB4A RAB4A, member RAS oncogene family 2.21538
BACE2 beta-site APP-cleaving enzyme 2 2.20915
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.20372
MRPS18A mitochondrial ribosomal protein S18A 2.1664
LOC102724594 splicing factor U2AF 35 kDa subunit 2.16617
GATA2 GATA binding protein 2 2.13686
ATF7IP2 activating transcription factor 7 interacting protein 2 2.13603
DPEP1 dipeptidase 1 (renal) 2.10428
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.09218
ANOS1 anosmin 1 2.08695
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.0279
TMEM50B transmembrane protein 50B 2.01743

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.79066
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.61545
MSMO1 methylsterol monooxygenase 1 -4.01796
SMC1A structural maintenance of chromosomes 1A -3.82861
REEP5 receptor accessory protein 5 -3.55852
TIMP1 TIMP metallopeptidase inhibitor 1 -3.55719
IGFBP7 insulin-like growth factor binding protein 7 -2.73761
CAPN2 calpain 2, (m/II) large subunit -2.71965
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.49106
KDM6A lysine (K)-specific demethylase 6A -2.43857
XPOT exportin, tRNA -2.34573
PUDP pseudouridine 5'-phosphatase -2.29644
CERS2 ceramide synthase 2 -2.29458
TRIB3 tribbles pseudokinase 3 -2.27524
KDM5C lysine (K)-specific demethylase 5C -2.25698
UBA1 ubiquitin-like modifier activating enzyme 1 -2.24561
RAB11A RAB11A, member RAS oncogene family -2.24372
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.20033
MT2A metallothionein 2A -2.16445
FN1 fibronectin 1 -2.16429
TSPOAP1 TSPO associated protein 1 -2.13945
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.12442
CHMP5 charged multivesicular body protein 5 -2.09113
TRAPPC3 trafficking protein particle complex 3 -2.06394
EMC7 ER membrane protein complex subunit 7 -2.04571
ANPEP alanyl (membrane) aminopeptidase -2.01721
MACIR macrophage immunometabolism regulator -2.01046