CRCGN016_MCF10A.TP53.M_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 9.41937
HMOX1 heme oxygenase 1 6.73225
GCLM glutamate-cysteine ligase, modifier subunit 3.78232
TSKU tsukushi, small leucine rich proteoglycan 3.45963
CTSL cathepsin L 3.43514
NQO1 NAD(P)H dehydrogenase, quinone 1 3.23892
CETN3 centrin, EF-hand protein, 3 3.11934
CBR1 carbonyl reductase 1 3.06771
MAP7 microtubule-associated protein 7 2.98238
UGDH UDP-glucose 6-dehydrogenase 2.94329
CBR3 carbonyl reductase 3 2.72987
GCLC glutamate-cysteine ligase, catalytic subunit 2.55976
SQSTM1 sequestosome 1 2.49784
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.4074
GLRX glutaredoxin (thioltransferase) 2.39593
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.35242
HBA1 hemoglobin, alpha 1 2.3162
ASF1A anti-silencing function 1A histone chaperone 2.3139
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.30909
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.27672
PFN2 profilin 2 2.22485
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.22408
PIR pirin (iron-binding nuclear protein) 2.13444
AKR1C3 aldo-keto reductase family 1, member C3 2.13395
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.12655
GSR glutathione reductase 2.1065
KEAP1 kelch-like ECH-associated protein 1 2.0916
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 2.05692
BAG2 BCL2-associated athanogene 2 2.0514

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -4.67737
NLRP4 NLR family, pyrin domain containing 4 -3.96495
TUBB6 tubulin, beta 6 class V -3.41596
DYNLT3 dynein, light chain, Tctex-type 3 -3.29822
CTNND1 catenin (cadherin-associated protein), delta 1 -3.12461
WASHC4 WASH complex subunit 4 -2.91941
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.88416
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.84421
MT1X metallothionein 1X -2.59666
SMC1A structural maintenance of chromosomes 1A -2.29026
CD79B CD79b molecule, immunoglobulin-associated beta -2.20975
PNMA8A PNMA family member 8A -2.20636
ARMCX1 armadillo repeat containing, X-linked 1 -2.2057
FAT2 FAT atypical cadherin 2 -2.19703
EPS8L1 EPS8-like 1 -2.1693
TRAPPC6A trafficking protein particle complex 6A -2.12767
EXT1 exostosin glycosyltransferase 1 -2.12379
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.10047
BASP1 brain abundant, membrane attached signal protein 1 -2.09151