CRCGN016_MCF10A.TP53.M_24H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 5.9795
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.95792
USP6NL USP6 N-terminal like 3.45734
GCLM glutamate-cysteine ligase, modifier subunit 2.67466
HMOX1 heme oxygenase 1 2.40497
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.33012
MCUR1 mitochondrial calcium uniporter regulator 1 2.18453
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.08487
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.01466

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -3.82691
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.73521
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.67317
DSG2 desmoglein 2 -3.66129
SGK1 serum/glucocorticoid regulated kinase 1 -3.56485
HMG20B high mobility group 20B -3.21726
TUBB6 tubulin, beta 6 class V -2.95351
DNM1L dynamin 1-like -2.70675
TXNDC9 thioredoxin domain containing 9 -2.56364