CRCGN016_MCF10A.TP53.M_24H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tert-butylhydroquinone 11.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 4.14494
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.00972
TRIM13 tripartite motif containing 13 3.92115
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.4248
TLR4 toll-like receptor 4 2.76888
WIF1 WNT inhibitory factor 1 2.59127
ZMIZ1 zinc finger, MIZ-type containing 1 2.32606
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.12796
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.09223
HNRNPM heterogeneous nuclear ribonucleoprotein M 2.0148

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -3.58139
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.4068
CD44 CD44 molecule (Indian blood group) -3.22649
CAB39 calcium binding protein 39 -3.09675
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.91733
ENOPH1 enolase-phosphatase 1 -2.91332
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.75448
PCNA proliferating cell nuclear antigen -2.62757
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.57476
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.55701
MSMO1 methylsterol monooxygenase 1 -2.53569
SGK1 serum/glucocorticoid regulated kinase 1 -2.51528
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.5134
CETN2 centrin, EF-hand protein, 2 -2.42712
FOS FBJ murine osteosarcoma viral oncogene homolog -2.33774
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.22983
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.2249
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.1976
CLTB clathrin, light chain B -2.16248
PANK2 pantothenate kinase 2 -2.1593
LY86 lymphocyte antigen 86 -2.09563
COPS4 COP9 signalosome subunit 4 -2.09179
KRT76 keratin 76, type II -2.0272
RGS2 regulator of G-protein signaling 2 -2.019
RAP1A RAP1A, member of RAS oncogene family -2.01864