CRCGN016_MCF10A.TP53.M_24H:H23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2-bis(bromomethyl)-1,3-pro?panediol, technical grade 34.02 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:H23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.02456
TLR4 toll-like receptor 4 4.67673
MTA2 metastasis associated 1 family, member 2 3.61503
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.40598
ELAVL1 ELAV like RNA binding protein 1 3.24879
ZNF586 zinc finger protein 586 3.16878
MDM4 MDM4, p53 regulator 3.02349
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.96607
PTPRJ protein tyrosine phosphatase, receptor type, J 2.80739
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.71296
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.56798
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.51514
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.44436
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 2.4331
NUTF2 nuclear transport factor 2 2.41573
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.41371
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.3885
STAT2 signal transducer and activator of transcription 2, 113kDa 2.3836
DOCK5 dedicator of cytokinesis 5 2.38353
ACAA1 acetyl-CoA acyltransferase 1 2.36949
CFP complement factor properdin 2.34065
FPR2 formyl peptide receptor 2 2.32482
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.31752
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.31199
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.28555
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.25001
ADPRH ADP-ribosylarginine hydrolase 2.24703
DMXL2 Dmx-like 2 2.23704
WFS1 Wolfram syndrome 1 (wolframin) 2.21965
STK17B serine/threonine kinase 17b 2.21958
PDCD1LG2 programmed cell death 1 ligand 2 2.21484
PLA2G2D phospholipase A2, group IID 2.18035
CCDC92 coiled-coil domain containing 92 2.17583
PRR16 proline rich 16 2.15193
KCTD20 potassium channel tetramerization domain containing 20 2.15142
TJP1 tight junction protein 1 2.13993
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.13965
KRT34 keratin 34, type I 2.13466
INCENP inner centromere protein antigens 135/155kDa 2.12842
TLCD3A TLC domain containing 3A 2.12558
ADGRE1 adhesion G protein-coupled receptor E1 2.1168
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.11396
ZNF665 zinc finger protein 665 2.11289
DEFB126 defensin, beta 126 2.11206
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.07397
WIF1 WNT inhibitory factor 1 2.06436
RBBP5 retinoblastoma binding protein 5 2.06262
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.05769
STK32B serine/threonine kinase 32B 2.05517
ZNF544 zinc finger protein 544 2.02587
GRHL2 grainyhead-like 2 (Drosophila) 2.01933

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -6.17952
PCCB propionyl CoA carboxylase, beta polypeptide -4.8954
RPA3 replication protein A3, 14kDa -3.98416
NRIP1 nuclear receptor interacting protein 1 -3.90319
LYPLA1 lysophospholipase I -3.71182
CORO1A coronin, actin binding protein, 1A -3.49956
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.51238
ADI1 acireductone dioxygenase 1 -2.51144
TUBA4A tubulin, alpha 4a -2.35048
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.33532
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.07074
PNPO pyridoxamine 5'-phosphate oxidase -2.04304
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -2.00132