CRCGN016_MCF10A.TP53.M_24H:I10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-chloroaniline 100.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 6.37741
PDLIM1 PDZ and LIM domain 1 5.621
SSBP2 single-stranded DNA binding protein 2 5.13416
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 5.10558
CIAO3 cytosolic iron-sulfur assembly component 3 4.73275
KLHL9 kelch-like family member 9 4.11492
TCTN1 tectonic family member 1 3.57544
COMP cartilage oligomeric matrix protein 3.55132
SYN1 synapsin I 2.96065
SOCS2 suppressor of cytokine signaling 2 2.95838
IQGAP1 IQ motif containing GTPase activating protein 1 2.90349
CNRIP1 cannabinoid receptor interacting protein 1 2.83631
ASTN2 astrotactin 2 2.7799
IL13RA1 interleukin 13 receptor, alpha 1 2.77124
TMEM43 transmembrane protein 43 2.76924
ITGA10 integrin, alpha 10 2.65306
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.64465
SYT1 synaptotagmin I 2.63012
VGLL4 vestigial-like family member 4 2.62834
SCGN secretagogin, EF-hand calcium binding protein 2.59084
CCL2 chemokine (C-C motif) ligand 2 2.59
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.58901
CENPC centromere protein C 2.47771
ANKRD49 ankyrin repeat domain 49 2.45923
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.45302
PARP16 poly (ADP-ribose) polymerase family, member 16 2.42934
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.33425
COL1A2 collagen, type I, alpha 2 2.31211
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 2.31049
CEP15 centrosomal protein 15 2.30887
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.29234
INA internexin neuronal intermediate filament protein, alpha 2.285
RUNDC3A RUN domain containing 3A 2.2717
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 2.26047
XPC xeroderma pigmentosum, complementation group C 2.20652
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.1629
WDR91 WD repeat domain 91 2.15956
ATF7IP2 activating transcription factor 7 interacting protein 2 2.15782
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.15044
CADPS2 Ca++-dependent secretion activator 2 2.14947
PADI3 peptidyl arginine deiminase, type III 2.13853
STMN2 stathmin 2 2.11857
MEGF9 multiple EGF-like-domains 9 2.11246
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 2.09016
TTLL7 tubulin tyrosine ligase-like family member 7 2.08941
LRRC49 leucine rich repeat containing 49 2.0612
OR7A5 olfactory receptor, family 7, subfamily A, member 5 2.05801
NCSTN nicastrin 2.04721
GLCE glucuronic acid epimerase 2.04436
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.04095
RASL12 RAS-like, family 12 2.03983
CRYM crystallin, mu 2.03057
ITGA9 integrin, alpha 9 2.02652
FOCAD focadhesin 2.02445
STEAP3 STEAP family member 3, metalloreductase 2.02102
TBC1D5 TBC1 domain family, member 5 2.01992
S1PR4 sphingosine-1-phosphate receptor 4 2.01223
TDRD12 tudor domain containing 12 2.00833
NSG2 neuronal vesicle trafficking associated 2 2.00794
ELANE elastase, neutrophil expressed 2.00534
YPEL5 yippee-like 5 (Drosophila) 2.00414

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -6.06905
C2CD5 C2 calcium-dependent domain containing 5 -5.93137
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -4.50673
NUSAP1 nucleolar and spindle associated protein 1 -3.58338
DEGS1 delta(4)-desaturase, sphingolipid 1 -3.47289
TUBA4A tubulin, alpha 4a -3.20069
NVL nuclear VCP-like -3.18477
EXOSC4 exosome component 4 -3.14617
ATG3 autophagy related 3 -3.0299
ZWINT ZW10 interacting kinetochore protein -2.95924
TTC13 tetratricopeptide repeat domain 13 -2.5784
PCNA proliferating cell nuclear antigen -2.56067
PTTG1 pituitary tumor-transforming 1 -2.55475
GTPBP8 GTP-binding protein 8 (putative) -2.54566
THAP11 THAP domain containing 11 -2.51234
SURF2 surfeit 2 -2.43679
MEA1 male-enhanced antigen 1 -2.41939
RNF187 ring finger protein 187 -2.41823
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.33048
PFN1 profilin 1 -2.28062
NPDC1 neural proliferation, differentiation and control, 1 -2.23781
CAMK1 calcium/calmodulin-dependent protein kinase I -2.19013
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.18115
AK6 adenylate kinase 6 -2.16751
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.14764
ATP5F1E ATP synthase F1 subunit epsilon -2.1204
SGK1 serum/glucocorticoid regulated kinase 1 -2.1183
RNF139 ring finger protein 139 -2.1089
EMC6 ER membrane protein complex subunit 6 -2.07297
KRT14 keratin 14, type I -2.06163
MRPS2 mitochondrial ribosomal protein S2 -2.05939
GOLGA8F golgin A8 family, member F -2.0492
NOP10 NOP10 ribonucleoprotein -2.04456
DUSP4 dual specificity phosphatase 4 -2.0394
GNG10 guanine nucleotide binding protein (G protein), gamma 10 -2.03224
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.0219
POMP proteasome maturation protein -2.00486
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.00416