CRCGN016_MCF10A.TP53.M_24H:I13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triphenyl phosphate 99.3 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:I13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 6.42537
CCP110 centriolar coiled coil protein 110kDa 3.83956
MYLK myosin light chain kinase 3.55068
FKBP14 FK506 binding protein 14, 22 kDa 3.46542
TLR4 toll-like receptor 4 3.44222
MAMLD1 mastermind-like domain containing 1 3.37951
NUP133 nucleoporin 133kDa 3.04018
WIF1 WNT inhibitory factor 1 3.02108
DAD1 defender against cell death 1 2.92088
ZNF451 zinc finger protein 451 2.84355
SATB1 SATB homeobox 1 2.54954
GPER1 G protein-coupled estrogen receptor 1 2.53615
ZMIZ1 zinc finger, MIZ-type containing 1 2.47524
ADAT1 adenosine deaminase, tRNA-specific 1 2.45447
UGDH UDP-glucose 6-dehydrogenase 2.43159
GRAMD2B GRAM domain containing 2B 2.3387
RBM15B RNA binding motif protein 15B 2.3111
GPATCH1 G patch domain containing 1 2.27307
GBP2 guanylate binding protein 2, interferon-inducible 2.21325
IGF1R insulin-like growth factor 1 receptor 2.10355
GDE1 glycerophosphodiester phosphodiesterase 1 2.02967
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.0083

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -6.67111
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.45351
SGK1 serum/glucocorticoid regulated kinase 1 -3.8853
MAPK13 mitogen-activated protein kinase 13 -3.65002
GADD45B growth arrest and DNA-damage-inducible, beta -3.3589
FPGS folylpolyglutamate synthase -3.30317
HMG20B high mobility group 20B -3.25022
ANXA2 annexin A2 -3.20543
TCEA2 transcription elongation factor A (SII), 2 -3.12797
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.10496
PRPF4 pre-mRNA processing factor 4 -3.08632
DNM1L dynamin 1-like -2.83159
OAT ornithine aminotransferase -2.62414
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.61825
NRIP1 nuclear receptor interacting protein 1 -2.60011
CDK9 cyclin-dependent kinase 9 -2.49345
BSPRY B-box and SPRY domain containing -2.42995
UBE2W ubiquitin-conjugating enzyme E2W (putative) -2.42157
DCK deoxycytidine kinase -2.30883
CDC73 cell division cycle 73 -2.30368
TUBB4B tubulin, beta 4B class IVb -2.25157
KLF6 Kruppel-like factor 6 -2.2341
BIK BCL2-interacting killer (apoptosis-inducing) -2.2004
EZR ezrin -2.17286
CREB1 cAMP responsive element binding protein 1 -2.1654
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.16108
GOLT1A golgi transport 1A -2.15151
MFSD12 major facilitator superfamily domain containing 12 -2.13804
FCHSD2 FCH and double SH3 domains 2 -2.09458
TM7SF3 transmembrane 7 superfamily member 3 -2.07985
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.0645
TUBB2A tubulin, beta 2A class IIa -2.03819
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -2.03757
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.03351
NLRP2 NLR family, pyrin domain containing 2 -2.03015
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.02135
RAP1B RAP1B, member of RAS oncogene family -2.01503
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.00733
RABEPK Rab9 effector protein with kelch motifs -2.00248