CRCGN016_MCF10A.TP53.M_24H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichlorobenzene 33.6 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

111 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.34155
SNAP25 synaptosomal-associated protein, 25kDa 5.03448
CLNS1A chloride channel, nucleotide-sensitive, 1A 4.93245
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 4.92637
FOS FBJ murine osteosarcoma viral oncogene homolog 4.92448
RSF1 remodeling and spacing factor 1 3.52369
TIAM1 T-cell lymphoma invasion and metastasis 1 3.50889
ALG8 ALG8, alpha-1,3-glucosyltransferase 3.42711
RBM15B RNA binding motif protein 15B 3.38521
AAMDC adipogenesis associated, Mth938 domain containing 3.32757
RNMT RNA (guanine-7-) methyltransferase 3.06737
ATP8B4 ATPase, class I, type 8B, member 4 3.03655
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.03346
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 3.01878
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.98894
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.86575
ARHGAP1 Rho GTPase activating protein 1 2.85338
UGDH UDP-glucose 6-dehydrogenase 2.84184
CNRIP1 cannabinoid receptor interacting protein 1 2.71434
CEP192 centrosomal protein 192kDa 2.71034
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.68885
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.68544
PKN1 protein kinase N1 2.66844
CCL1 chemokine (C-C motif) ligand 1 2.58995
UVRAG UV radiation resistance associated 2.58958
SNAP91 synaptosomal-associated protein, 91kDa 2.57483
HOXB9 homeobox B9 2.54068
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.46225
TLR7 toll-like receptor 7 2.42239
DOCK2 dedicator of cytokinesis 2 2.40881
IL9 interleukin 9 2.35336
GAB2 GRB2-associated binding protein 2 2.34775
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.32894
PNMA8A PNMA family member 8A 2.31522
TMLHE trimethyllysine hydroxylase, epsilon 2.30927
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.27244
PTPRG protein tyrosine phosphatase, receptor type, G 2.25603
DENND2D DENN/MADD domain containing 2D 2.25576
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.25355
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.2436
VSNL1 visinin-like 1 2.23922
HSPA1L heat shock 70kDa protein 1-like 2.22554
IREB2 iron-responsive element binding protein 2 2.22043
SEH1L SEH1-like (S. cerevisiae) 2.1922
NME4 NME/NM23 nucleoside diphosphate kinase 4 2.18763
CDH18 cadherin 18, type 2 2.17416
STMN2 stathmin 2 2.17176
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.17164
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.16156
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.16154
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.16144
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.15773
WASHC3 WASH complex subunit 3 2.14706
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 2.1327
RNF170 ring finger protein 170 2.1176
MTM1 myotubularin 1 2.1137
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.10899
THAP12 THAP domain containing 12 2.10329
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.10113
CAPN5 calpain 5 2.09944
PCDHGA3 protocadherin gamma subfamily A, 3 2.09875
LGALS14 lectin, galactoside-binding, soluble, 14 2.09108
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.0895
SV2B synaptic vesicle glycoprotein 2B 2.0833
ZNF493 zinc finger protein 493 2.07371
SNIP1 Smad nuclear interacting protein 1 2.07365
AFG3L2 AFG3-like AAA ATPase 2 2.07279
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.0688
R3HDM2 R3H domain containing 2 2.04549
ARID4A AT rich interactive domain 4A (RBP1-like) 2.04354
PRAMEF26 PRAME family member 26 2.03165
HIP1 huntingtin interacting protein 1 2.03116
ZBTB25 zinc finger and BTB domain containing 25 2.02685
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.02111
CLSTN2 calsyntenin 2 2.02109
SCN3B sodium channel, voltage gated, type III beta subunit 2.01454

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -5.2041
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.00383
HAT1 histone acetyltransferase 1 -4.92161
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.90297
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.72405
VDAC1 voltage-dependent anion channel 1 -4.64574
RNF167 ring finger protein 167 -4.41828
COTL1 coactosin-like F-actin binding protein 1 -3.52679
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.94397
BAD BCL2-associated agonist of cell death -2.80992
C1R complement component 1, r subcomponent -2.76901
IGFBP7 insulin-like growth factor binding protein 7 -2.70223
MPDU1 mannose-P-dolichol utilization defect 1 -2.67277
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.63568
AAMP angio-associated, migratory cell protein -2.59862
CHD8 chromodomain helicase DNA binding protein 8 -2.43543
HLA-F major histocompatibility complex, class I, F -2.36889
KRT14 keratin 14, type I -2.35875
GNLY granulysin -2.35424
FZD10 frizzled class receptor 10 -2.30223
NUCB1 nucleobindin 1 -2.24106
MSN moesin -2.2156
PLPP3 phospholipid phosphatase 3 -2.20961
C1S complement component 1, s subcomponent -2.17991
PLTP phospholipid transfer protein -2.17847
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -2.15847
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.15301
HLA-G major histocompatibility complex, class I, G -2.14206
PFN1 profilin 1 -2.09658
ZC3H12A zinc finger CCCH-type containing 12A -2.05731
KDM3A lysine (K)-specific demethylase 3A -2.03205
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) -2.02311
SDF4 stromal cell derived factor 4 -2.02145
PCDH17 protocadherin 17 -2.0023
CD8A CD8a molecule -2.00223